J Pharm Pharmacogn Res 2(Suppl. 1): S27, 2014
Special supplement with the abstract book of LATINFARMA 2013
C 008: THE RATIONALE OF ANALGESIS COMBINATIONS
Granizo E.Universidad Central de Ecuador.
No single analgesic agent is perfect and no single analgesic can treat all types of pain. Oral fixed drug combinations analgesics potentially have a number of advantages over monotherapy, but these benefits can only be attained through careful design that is not the case in some available preparations.
A combination is most effective when the individual agents act through different analgesic mechanisms and act synergistically. The fixed-dose combinations analgesics are of value only when they have bee developed according to rationale pharmacokinetic and pharmacodynamic criteria.
This overview highlights the therapeutic potential of combining analgesic medications with different mechanisms of action like a NSAIDs drugs or acetaminophen with an opioid or tramadol.