J Pharm Pharmacogn Res 2(Suppl. 1): S141, 2014
Special supplement with the abstract book of LATINFARMA 2013
C 047: CHRONOPHARMACOLOGY
Biological rhythms influence many body functions like metabolism, sleep pattern, hormone production and physiology. Variations in these functions cause changes both in disease state and in plasma drug concentrations. Diseases, such as hypertension, asthma, peptic ulcer, arthritis, myocardial infarction, congestive heart failure, stroke, cancer, follow the body’s circadian rhythm. Many systems in the human body such as hepatic and renal systems show variation in their function throughout a typical day. They are predictable systems, which require different amounts of drug at predictably different times within the circadian cycle in order to maximize desired and minimize undesired drug effect. Chronopharmacology considers that the drug therapy can be optimized by tailoring the dosing schedule based on chronobiological pattern. This has led to a new approach to the development of drug delivery systems. A number of chronotherapeutic medications, aiming at synchronizing medications and the intrinsic rhythms of disease have been developed in recent years. In this lecture, the concepts of biological rhythms, chronobiology, chronopharmacology and chronotherapy for various diseases will be discussed.