CO 006: CONCENTRATION OF MMP-3 AND IL-6 IN PATIENTS WITH SEPSIS AND MULTIORGAN FAILURE

J Pharm Pharmacogn Res 2(Suppl. 1): S4, 2014

Special supplement with the abstract book of LATINFARMA 2013

Oral Communication

CO 006: CONCENTRATION OF MMP-3 AND IL-6 IN PATIENTS WITH SEPSIS AND MULTIORGAN FAILURE

Ricarte Bratti JP, Montrull HL, Meirovich CI, Jaime NJ, Demurtas SL, Brizuela NY.

Universidad Nacional de Córdoba – Fac Cs Medicas – Cátedra de Farmacología. Santa Rosa 1085, Córdoba, Argentina. E-mail: jpricarte@yahoo.com.ar
Abstract

Introduction: Sepsis is the leading cause of mortality in intensive care. The study of its pathophysiology is essential to try to change the high mortality that this syndrome presents. The multiple organ dysfunction Syndrome (MODS) is a high mortality syndrome caused by sepsis. Cytokines are the main responsible for the inflammatory response in sepsis and MODS, including IL-1, 6 and TNF alpha. MMP-3 is a molecule relatively recent that has not been studied in sepsis yet.

Aim: To assess the predictive power of cytokines on MODS and death.

Material and methods: 48 patients older than 18 years with sepsis criteria who were attended the Hospital Nacional de Clínicas of Cordoba-Argentina have been included. Upon admission blood samples were drawn for the dosage of cytokines.

Results: Patients with MODS had a mean value of IL-6 of 210.10 ± 30.82 pg/mL and for patients without MODS of 155.32 ± 20.84 pg/mL (p=0.135). For MMP-3 MODS patients had an average of 14.57 ± 0.63 mg/mL whereas patients who did not develop MODS reached an average of 9.8 ± 0.83 mg/mL (p<0.0001). Evaluating mortality IL-6 in death patients was a medium term of 203.65 ± 26.64 pg/mL in slight contrast to the survivors, whose average was 161.88 ± 24.38 pg/mL, giving a difference without statistical significance (p = 0.26). Values of MMP-3 in survivors had an average of 10.55 ± 0.76 mg/mL, whereas the average of the deceased was 13.77 ± 0.98 mg/mL (p=0.012).

Conclusions: MMP-3 has shown that if at the time of admission it´s in a high value (Beyond 12 mg/mL) has a prognostic value since it predicts death and organ failure. IL-6 has a tendency to the above, but with nonsignificant results, so more studies are needed with larger numbers of patients.