J Pharm Pharmacogn Res 2(Suppl. 1): S9, 2014
Special supplement with the abstract book of LATINFARMA 2013
CO 019: SERUM LEVELS OF INFLAMMATORY MARKERS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION DURING A 6 MONTH FOLLOW UP
Brizuela NY, Ricarte Bratti JP, Vergottini JC, Ponce LN and Menara A.Cátedra Farmacología General. Facultad de Ciencias Médicas. Universidad Nacional de Córdoba. Santa Rosa 1085. (5000), Córdoba. Argentina. E-mail: firstname.lastname@example.org, email@example.com
Introduction: The inflammation plays a fundamental role in pathogenesis and complication of the atherosclerosis. Cytokines and adhesion molecules are key components of these events that contribute to the development of an atherosclerotic plaque. Their determination of plasma levels provides an excellent reflection of the underlying inflammatory process, since it is positively correlated with other markers such as pro-inflammatory cytokines. The cytokine Tumor necrosis factor alpha (TNF-α), the interleukin-6 (IL-6) and vascular adhesion molecule-1 (VCAM-1) are indicators of basal inflammation. This study reports on the follow-up of 27 patients, aged 42–82 years with confirmed acute myocardial infarction (AMI group) and a matched control group of 10 patients without coronary artery disease (control group).
Material and methods: Blood samples for determination of inflammatory markers were taken on the 3rd day and after 6 months. Concentrations of cytokines and adhesion molecules were measured using commercial Immunoassay (ELISA) kits (Amersham Sciences).
Results: The serum level of VCAM-1 in the AMI group was significantly higher than in control groups (P<0.01). In the acute phase of myocardial infarction (MI) the levels of TNF-α and IL-6 were higher than in the control group (P<0.01). Six months later the levels of TNFα, IL-6 and ICAM-1 normalized (P<0.001).
Conclusions: The present study showed that in the acute phase of AMI increased activation of pro inflammatory markers. In the course of healing within 6 months after the infarction the inflammatory reaction disappears. It is necessary to carry out further studies to clarify the role of adhesion molecules in acute coronary syndrome. Future studies of the prediction of recurrent vascular events after AMI should concentrate on clinical variables and different blood inflammatory markers.