J Pharm Pharmacogn Res 2(Suppl. 1): S33, 2014
Special supplement with the abstract book of LATINFARMA 2013
CO 055: NANOEMULSION PREPARATIONS FROM A PLANT LIPID EXTRACT WITH WIDE RANGE OF APPLICATIONS IN MEDICINE
Turiño L1, González E2, Nogueira A3, López O3.
Introduction: The lipid extracts from vegetal origin have shown a very effective activity on the different mechanisms related to Benign Prostatic Hyperplasia. The oil obtained from the seeds of the Cuban pumpkin species Cucurbita pepo L., is an example of natural components useful for men who suffer this common hypertrophy. The administration of oily components by oral way as nanocapsules would be a variant of minimal invasion consumption and would also represent a strategy for favoring the absorption and bioavailability of the product.
Material and methods: In this work, the main objective was to obtain nanoemulsions by means of a high-energy method called High-speed Homogenization, using lipid extract from the seeds of Cucurbita pepo L. as a dispersed phase. The droplet size determination was performed by the diffraction method, Induced Grating. Through an experimental design, the influence of three speed levels (9500, 13500 and 20500/min) and three distance from the disperser to the bottom of the vessel, where the nanoemulsions were prepared (5, 10 and 15 mm) on droplet diameter were evaluated.
Results: It was shown statistically that for the studied values related to the distance from the disperser to the bottom, any significant difference was obtained, not being this the case the effect shown by the speed, since for the highest level of speed, a diameter 10 times lower (11.64 nm) relative to the one achieved with the minimum operation speed was reached.
Conclusions: The result obtained in this investigation showed that by subjecting the system to a high degree of shear, a significant reduction of the droplet size in the oil phase is guaranteed, which has an impact on absorption, due to the small size reached.