CO 056: DEVELOPMENT AND CHARACTERIZATION OF MANGIFERIN NANOCAPSULES

J Pharm Pharmacogn Res 2(Suppl. 1): S34, 2014

Special supplement with the abstract book of LATINFARMA 2013

Oral Communication

CO 056: DEVELOPMENT AND CHARACTERIZATION OF MANGIFERIN NANOCAPSULES

Moura UJ, Barbosa MG, Genro C, Seibel D, Gomes P, Raffin PR.

Centro Universitário Franciscano. Rua dos Andradas, 1614, Santa Maria-RS, Brasil.
Abstract

Introduction: Manginferin (1,3,6,7-tetrahydroxi-xantona-C2-b-Dglucosilada) is a natural bioactive, more specifically a glycosylated xanthone isolated from Mangifera indica L. Mangiferin is the main component of mango extract that presents pharmacological activities on different organs and tissues, promoting preventive and therapeutic effects against a considerable number of diseases. However, one of the problems of mangiferin is its low solubility in water and the poor chemical stability. In this way, nanoencapsulation can be a promising tool to improve mangiferin bioavailability and stability in order to develop new medicines.

The objectives of this study were developed and characterize a nanoencapsulated formulation containing mangiferin and evaluate the physico-chemical characteristics of this nanosystem.

Material and methods: The interfacial deposition of preformed polymer technique was used to produce nanocapsules. It was necessary to add small amounts of DMSO in order to solubilize mangiferin in the organic phase. Mangifrin was encapsulated at 0.025%. Particle size, polydispersity index and zeta potential were evaluated in ZetaSizer NanoSeries. pH was assessed directly into the colloidal suspensions. Drug content and drug release experiments (dialysis) were analyzed in HPLC through a validated method.

Results: Nanocapsules were successfully obtained using Eudragit S100 as polymer. Particle size was 96.37 nm, polydispersity index was 0.202 and zeta potential was -16.63 mV. pH was 3.42. The results showed no significant difference (p < 0.05) between nanocapsules with and without mangiferin. Encapsulation efficiency was obtained by ultrafiltration/centrifugation and it was approximately 80.0%. Drug release profiles showed that mangiferin was released from nanocapsules half of the amount than free mangiferin, demonstrating a controlled profile.

Conclusions: Based on these results, we can conclude that mangiferin nanocapsules were developed with adequate characteristics for biological experiments.

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