CO 057: COMBINATION EFFECT OF SONOPHORESIS AND IONTOPHORESIS ON ANTIPYRINE TRANSDERMAL PENETRATION

J Pharm Pharmacogn Res 2(Suppl. 1): S35, 2014

Special supplement with the abstract book of LATINFARMA 2013

Oral Communication

CO 057: COMBINATION EFFECT OF SONOPHORESIS AND IONTOPHORESIS ON ANTIPYRINE TRANSDERMAL PENETRATION

Aoyagi T1, Watanabe S2, Ga K2, Yamamoto K3.

1National Institute for Materials Science, 1-1, Namiki, Tsukuba, Ibaraki 305-0044, Japan. E-mail: aoyagi.takao@nims.go.jp
2Yutoku Pharmaceutical Ind. Co., Japan.
3Kagoshima University, Japan.
Abstract

Introduction: Transdermal drug delivery is promising method to administrate unstable drugs in digestive organs or avoids first pass effect. To promote the drug penetration, sonophoresis and iontophoresis are very effective as physical enhancing methods. The each enhancing effects have been widely studied and actually there are many reports. In this study, we investigated the combination effect of sonophoresis and iontophoresis of transdermal penetration of antipyrene as model drug.

Material and method: We used Sonoion® was used to achieve the objective. It is developed by Kagoshima Supersonic Laboratory Co., Ltd. The excised back and abdominal skin of hairless mouse was used to estimate the enhanced condition of Sonoion® such as current, voltage and order of application (sono. to ionto. or ionto. to sono.) and so on. The animal is established by Kyudo Co., in Kumamoto, Japan. The excised skin was set in Franz-type cell and the Sonoion® was applied. The temperature was kept in 37°C.

Results: The combination of sonophoresis and iontophoresis showed synergy effect on the antipyrine skin permeation. By Field-Emission scanning electron microscopy (FE-SEM), the some small holes in stratum corneum was observed by sonophoresis apply. In terms of the order of application, the higher effect was obtained by first sonophoresis application. Moreover, the long drug release was observed by only short time application of Sonoion®.

Conclusion: The combination of sonophoresis andiontophoresis is very effective to enhance drug permeation and long-time drug release. Such effect would be based on the small holes formation and deposition of the drug molecules in stratum corneum.