J Pharm Pharmacogn Res 3(suppl. 1): S6, 2015
Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.
L-06: DEVELOPMENT OF NATURAL PRODUCT DRUGS IN A SUSTAINABLE MANNER, AN EXPERIENCE OF CENTER FOR PHARMACEUTICAL RESEARCH AND DRUG DEVELOPMENT
Centro de Investigación y Desarrollo de Medicamentos (CIDEM), Ave.26 No.1605 e/ Boyeros y Puentes Grandes, La Habana, Cuba. E-mail: firstname.lastname@example.org
Around half of the drugs currently in clinical use are of natural product origin; this is the most consistently successful source of drug leads. Despite this statistic, pharmaceutical companies have embraced the era of combinatorial chemistry, neglecting the development of natural products as potential drug candidates in favor of high-throughput synthesis of large compound libraries. Perhaps it is time to reassess this prevailing dogma for chasing quantity over quality. Natural products continue to provide greater structural diversity than standard combinatorial chemistry and so they offer major opportunities for finding novel low molecular weight lead structures that are active against a wide range of assay targets. As less than 10% of the world’s biodiversity has been tested for biological activity, many more useful natural lead compounds are awaiting discovery. The challenge, is how to bridging the gap between traditional medicine and modern medicine. Our answer is applying the same scientific strictness to the development of natural products than for the synthetics, getting closer to the standardization of phytomedicine, using methods to verify the authenticity of the vegetal material and considering safety issues, as being free from harmful materials like toxic insecticides, pesticides and heavy metals, microbial and radioactive contamination. The extracts should be then checked for cytotoxic, mutagenic and therapeutic perspective in experimental animal models. During the last four decades, the CIDEM has been strengthened its capabilities to develop organic farming on sustainable manner; in the taxonomic, chemical, and biological evaluation of new drugs and on application of advanced technology in formulations design; leading development projects for the national industry and with the scale up of more than 45 natural products.
Citation Format: González N (2015) Development of natural product drugs in a sustainable manner, an experience of Center for Pharmaceutical Research and Drug Development. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S6. Abstract nr L-06.