L-07: OXIDATIVE STRESS REGULATION BY NATURAL ANTIOXIDANT COMPOUNDS

J Pharm Pharmacogn Res 3(suppl. 1): S7, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Lecture

L-07: OXIDATIVE STRESS REGULATION BY NATURAL ANTIOXIDANT COMPOUNDS: FROM EXPERIMENTAL DATA TO CLINICAL PRACTICE

Delgado-Roche L1, Venturi I2, Menéndez R1, Malheiros A2, de Souza MM2, Filho VC2, Fernández MD1, Rodeiro I1.

1Department of Pharmacology, Center of Marine Bioproducts, Loma St. and 37, Nuevo Vedado, Plaza de la Revolución, Havana, Cuba. E-mail: livandelgado@infomed.sld.cu
2Universidade do Vale do Itajaí, Santa Catarina, Brazil.

 

Oxidative stress (OS) is an imbalance between the production of oxidants and the occurrence of cell antioxidant defenses, which disrupts redox signaling. This inevitable process has been implicated in the pathogenesis of a large number of human diseases. Several evidences show that naturally occurring compounds can protect cells from OS, ameliorating various related diseases, such as cardiovascular diseases, cancer, neurodegeneration, diabetes, inflammatory conditions and autoimmune disorders. The protective effect of natural antioxidants, alone or in combination, against lipid, protein and DNA oxidation has been extensively studied in humans and animal models. However, the clear understanding of precise mechanisms of actions of these compounds would shed further light into their application in the prevention and treatment of OS related diseases. The present work summarizes the state of the art in this field. Furthermore, we show the characterization of the in vitro and in vivo antioxidant activity of Solanum diploconos (SD) flowers. Our results demonstrated the scavenging capacity of SD against the formation of DPPH and superoxide anion radicals, as well as the inhibitory effect against the brain phospholipid peroxidation. In addition, the oral supplementation with SD extract (10, 100 and 200 mg/kg during a week) prevented the benzo(a)pyrene-induced oxidative stress in mice, protecting against liver damage. The in vivo antioxidant capacity of SD was also addressed in a mice model of cotton pellets-induced granuloma. The results showed a significant reduction (p<0.05) of granulomas weight, suggesting the anti-inflammatory effect of SD. Besides, SD protected against lipid and protein oxidation, together with a preservation of systemic glutathione levels. On the other hand, we discuss the results of some clinical trials aimed to evaluate the efficacy of natural products in the primary and secondary prevention of non-communicable chronic diseases.

Citation Format: Delgado-Roche L, Venturi I, Menéndez R, Malheiros A, de Souza MM, Filho VC, Fernández MD, Rodeiro I (2015) Oxidative stress regulation by natural antioxidant compounds: from experimental data to clinical practice. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S7. Abstract nr L-07.