L-09: ROLE OF METABOLIZING SYSTEMS AND TRANSPORTERS IN HERB-DRUG INTERACTIONS

J Pharm Pharmacogn Res 3(suppl. 1): S9, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Lecture

L-09: ROLE OF METABOLIZING SYSTEMS AND TRANSPORTERS IN HERB-DRUG INTERACTIONS, ITS IMPACT IN THE HUMAN HEALTH

Rodeiro I.

Department of Pharmacology, Center of Marine Bioproducts, Loma 37, Vedado, Havana City, Cuba. E-mail: idania.rodeiro@infomed.sld.cu

Herbal medicines have been widely used worldwide for centuries. A major cause of current concern is that herbal remedies may interact with medicinal drugs, altering the pharmacodynamic or pharmacokinetic characteristics of the latter and leading to clinically significant interactions. Herbs are taken not only by health persons who want to protect themselves from the onset of disease or to improve their well-being, but also by patients suffering from life-threatening conditions who simultaneously receive one or more medicinal drugs. Between others, these patients are subjected to suffering the effects derived from the co-administration of the herb and conventional drug, thus at the last years it is a point of discussion. Pharmacological interactions possibly derive from the modulation in expression and/or activity of two major pharmacokinetic disposition systems, namely cytochrome P450 (CYP) and the multidrug transporters where P-glycoprotein is identified as the major. Mixtures and compounds isolated from its have been identified as substrates, inhibitors or inducer of different cytochromes and/or transporters in humans. This works offers an overview of the knowledge about evidences on the in vitro and in vivo effects of natural products on human P450 enzymes and human variability in the modulatory response. Interactions of ginkgo, saw palmetto, hypericum, kava kava, ginseng, between other are revised. Effects observed on P450 system and P-glycoprotein after evaluation of natural products used during several years in the traditional medicine in Cuba is presented. The elucidation of these interactions may be important not only to predict possible undesirable effects deriving from the concomitant intake of herbals and conventional drugs, of these interactions as a way to increase the bioavailability of drugs that are P-gp substrates, as example. Thus, a better understanding of interactions of herbs with these systems will help the regulation of the use of herbs as drugs and food supplements.

Citation Format: Rodeiro I (2015) Role of metabolizing systems and transporters in herb-drug interactions, its impact in the human health. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S9. Abstract nr L-09.