L-10: PHYTODRUGS CAN INCREASE THE EFFICACY OF CANCER CLASSIC THERAPIES

J Pharm Pharmacogn Res 3(suppl. 1): S10, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Lecture

L-10: PHYTODRUGS CAN INCREASE THE EFFICACY OF CANCER CLASSIC THERAPIES

Letelier ME, Galindo H.

Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago-Chile. Centro del Cáncer, Pontificia Universidad Católica. Santiago-Chile. E-mail: mel@ciq.uchile.cl

Introduction: Cancer is a disease associated to chronic inflammation, which in turn is associated to oxidative stress. The cell regulates the redox unbalance by activating diverse cytokines (nuclear transcription factors, growth factors, inflammatory cytokines and cell cycle regulatory molecules). These processes are altered in tumour cells which favours their multiplication. The main problems of the anti-cancer chemotherapy are its lack of specificity and its serious adverse effects. The defence mechanisms of plants are similar to those of the animal cell. Therefore, phytodrugs capable of increasing the defences of the human organism should at least, diminish the adverse effects of classical anticancer therapy. Lung cancer drade 4 treated with classical chemotherapy has shown in Chile 15% tumour regression, maximum eight successive chemotherapies and only eight months of patient survival. Methods: The case of a patient diagnosed in June, 2013 who presented a primary lung tumour of 3.9 cm in diameter and a secondary pleural tumour of 1 cm is presented. From the date of diagnosis to date, the patient has received four chemotherapy that included cisplatin and pemetrexed and 27 with only pemetrexed. Since the beginning of the chemotherapy he has been also treated for all time with phytodrugs enriched in antioxidant, anti-inflammatory and immune system stimulators principles. Results: Cotherapy abolished gastrointestinal and hepatic adverse effects of conventional chemotherapy. Moreover, the last check made in July, 2015 showed the disappearance of pleural tumour and regression of the lung tumour of 50%.

Citation Format: Letelier ME, Galindo H (2015) Phytodrugs can increase the efficacy of cancer classic therapies. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S10. Abstract nr L-10.