OC-03: ANTIINFLAMMATORY AND ANTINOCICEPTIVE EFFECTS OF Cassia fistula LINN. (Fabaceae) FRUITS

J Pharm Pharmacogn Res 3(suppl. 1): S13, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Oral Communication

OC-03: ANTIINFLAMMATORY AND ANTINOCICEPTIVE EFFECTS OF Cassia fistula LINN. (Fabaceae) FRUITS

Palacios-Espinosa JF, Núñez-Peña L, Izquierdo-Sánchez T, Lozada-García MC.

Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana Unidad Xochimilco. Calzada del Hueso 1100, Col. Villa Quietud, Delegación Coyoacán, C.P. 04960, México D.F. E-mail: jpalacios@correo.xoc.uam.mx, tizquier@correo.xoc.uam.mx

Introduction: Cassia fistula L. is an ornamental Asian-native tropical tree. In Mexico it is also known as “Hoja sen” or golden rain and it is widely used for the treatment of gastrointestinal, inflammatory and painful conditions. Objective: To evaluate the antinociceptive and anti-inflammatory potential in vivo of three organic and one aqueous extracts (CFFH, CFFD, CFFM and CFFA, respectively) obtained from the fruit seedless of C. fistula. Material and Methods: The abdominal stretching induced with 0.7% acetic acid and TPA-induced ear edema in mice, were used. Similarly, the acute toxic effects were studied by Lorke´s Test. The extract with the best profile, a bioassay-guided phytochemical study was undergoes to isolate bioactive compounds. Results: In abdominal stretching model, at dose of 300 mg/kg, significant anti-nociceptive effects were observed in all extracts. CFFD was the best extract; it decreased 75.4% of stretching caused by acetic acid, immediately CFFH with 71.7%, CFFA 67.2% and CFFM with 54.4%. The reference drug group of metamizol (MET) had 87% of inhibition. For the anti-inflammatory effect, estimated as decreased of TPA-induced ear edema, the following percentages of inhibition were observed: 66% for CFFD, 41% for CFFM and 31% and 22% of CFFH and CFFA, respectively. Those were compared with indomethacin (INDO), which produced 72% of edema inhibition. From the CFFD´s bioassay-guided fractionation, cinnamic acid was obtained as white crystals with modest inhibitory activity on the auricular edema (27.3 %) and a good percentage of 77% inhibition of the abdominal stretching. Conclusions: The antinociceptive and anti-inflammatory activities are associated with the presence of active compounds in fruits of C. fistula. We are working to isolate additional bioactive products. This study provides evidence of ethno-medical use in traditional medicine in the region.

Citation Format: Palacios-Espinosa JF, Núñez-Peña L, Izquierdo-Sánchez T, Lozada-García MC (2015) Antiinflammatory and antinociceptive effects of Cassia fistula Linn. (Fabaceae) fruits. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S13. Abstract nr OC-03.