J Pharm Pharmacogn Res 3(suppl. 1): S26, 2015
Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.
OC-08: A HERBAL REMEDY MADE FROM SUBSPECIES OF Rosa canina (LITO), REDUCES SYMPTOMS OF OSTEOARTHRITIS AND THE CONSUMPTION OF PAIN KILLERS
Winther K1, Campbell-Tofte J2.
Objectives: The aim of this study was to test if a herbal remedy made from the fruits (rose-hip) of a subspecies of Rosa canina (Lito) might reduce symptoms of osteoarthritis of the hip or knee, as well as reduce the need for regular pain killers. Material and Methods: Ninety-four patients with osteoarthritis of the hip or knee were enrolled in a randomized, placebo-controlled and double-blinded cross-over clinical trial. Forty-seven patients were given 5 g of the rose-hip powder for a period of 3 months, while the rest received a similar amount of placebo. The group initially treated with placebo was then changed to rose-hip and vice versa for another 3 months period. Upon inclusion and after 3 weeks and at the end of the 3 months of each treatment period, symptoms of osteoarthritis such as pain, stiffness, daily activity and the patients personal evaluation of the disease severity were scored on a WOMAC questionnaire. Each day during the whole treatment period, the patients registered their consumption of rescue medication. After 3 weeks of treatment, the study participants were allowed to reduce their consumption of medication if this was considered tolerable. Data were analyzed on the intention to treat. Results: Active treatment resulted in a significant reduction in WOMAC pain score (p<0.013) as compared to placebo, when testing after three weeks of treatment. A similar pattern was observed for joint stiffness. WOMAC disability (ADL) and the patients evaluation of the severity of their disease decreased significantly (p<0.018 and p<0.035, respectively) when testing after three month treatment. The consumption of rescue medication such as paracetamol, synthetic opioids and codeine declined by 40% as a result of active treatment (p<0.031). Conclusions: The data suggests that the herbal remedy based on rose-hip made from Lito subspecies can alleviate symptoms of osteoarthritis and reduce replaced the consumption of rescue medication. It was calculated that if 50% of potential osteoarthritis patients reduce their use of rescue medication by taking this rose hip preparation, the savings to the society could be up to 666 Euro/osteoarthritic patient /year.
Citation Format: Winther K, Campbell-Tofte J (2015) A herbal remedy made from subspecies of Rosa canina (lito), reduces symptoms of osteoarthritis and the consumption of pain killers. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S26. Abstract nr OC-08.