OC-23: PHYTOCHEMICAL STUDY OF Croton linearis JACQ. LEAVES

J Pharm Pharmacogn Res 3(suppl. 1): S41, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Oral Communication

OC-23: PHYTOCHEMICAL STUDY OF Croton linearis JACQ. LEAVES

García J1, Escalona JC1, do Carvallo MG2, de la Vega J3, Rojas J4, Machado R4.

1Departamento de Farmacia, Facultad de Ciencias Naturales, Universidad de Oriente, Avenida Patricio Lumumba s/n, Santiago de Cuba, Cuba. E-mail: jgadi@cnt.uo.edu.cu, jcea@cnt.uo.edu.cu
2Departamento de Química, Instituto de Ciencias Exactas, Universidade Federal Rural de Rio, BR 465, Km 07, 23890-000-Seropédica-RJ, Brasil. E-mail: mgeraldo@ufrrj.br
3Centro de Toxicología y Biomedicina, Universidad de Ciencias Médicas; Autopista Nacional Km 1 ½, Santiago de Cuba, Cuba. E-mail: robertomg@cnt.uo.edu.cu
4Departamento de Química, Facultad de Ciencias Naturales, Universidad de Oriente, Avenida Patricio Lumumba s/n, Santiago de Cuba, Cuba. E-mail: jarojas@cnt.uo.edu.cu

 

Introduction: Cuban population to treat the fever usually uses leaves from Croton linearis Jacq., but there is almost no information about this plant; that’s why in the present work we accomplish a phytochemical study of C. linearis leaves. Material and Methods: By hydrodistillation-cohobation method, the essential oils were extracted to be characterized by Gas Chromatography – Mass Spectrometry. The non volatile compounds were separated by thin layer chromatography and colum chromatography. The isolated compounds were characterized by Nuclear Magnetic Resonance 1D (1H and 13C NMR), 2D (1H–H COSY, HMQC and HMBC); UV-visible spectroscopy and Mass Spectrometry. Results: Essential oil extraction yield 1.6% being identified 82 compounds with guaiol (7.93%), eudesma-4(15),7-dien-1β-ol (4.94%), guaia-3,10(14)-dien-11-ol (4.52%), selin-4(15),7(11)-diene (4.19%) y el β-elemene (4.13%) as the main constituents. Additionally, seven metabolites were identified as 5-hydroxy-3,7,4′-trimethoxyflavone, tetracosane, hexacosan-1-ol, 2-methyl-2-docosanol, as well as the acids oleic, stearic and the 5,8-dien-tetradecanoic. Conclusions: A total of 89 new compounds for this plant was reported, giving it a great pharmacological potentiality.

 

Citation Format: García J, Escalona JC, do Carvallo MG, de la Vega J, Rojas J, Machado R (2015) Phytochemical study of Croton linearis Jacq. leaves. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S41. Abstract nr OC-23.