J Pharm Pharmacogn Res 3(suppl. 1): S47, 2015
Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.
OC-28: ANTI-PLASMODIAL ACTIVITY OF Parthenium hysterophorus L. LACTONES
Fernández-Calienes A1, Fraga J1, Mendiola J1, Scull R2, Morier L1, Linares R1, Mendoza D1, Cuéllar A2.
Introduction: Previous studies compilate information about plant species with reports of antimalarial use in Cuba and demonstrate antiplasmodial activity of crude extracts from Parthenium hysterophorus L. This plant produces a wide variety of sesquiterpenoid lactones, between them, parthenin. This lactone showed activity against Plasmodium faciparum. The purpose of this study was to evaluate antiplasmodial activity of lactones rich-extracts from root and aerial part of P. hysterophorus. Methods: Four extracts were prepared, two lactones rich-extracts from root and aerial part and one fraction without lactones each. Extracts activity evaluated in vitro against P. berghei and citotoxicity against human fibroblast MRC-5 was determined. The most selective extract was evaluated in vivo in a murine model. Results: Both lactones rich-extracts showed 50% of P. berghei schizogony development inhibition at 100 mg/mL (aerial part 23.2 µg/mL and root 55.4 µg/mL), whereas, fractions “without lactones” were inactives to that concentration. Root lactones rich-extract showed the highest selectivity index (IS = 3.1) although the value could be considered as mild. Intraperitoneal treatment with root lactones rich-extract of P. hysterophorus was no toxic to animals. It caused parasitemia significative reduction in mice treated with 1000 mg/kg. Conclusions: These results reaffirm antiplasmodial action of P. hysterophorus root and show lactones implication on this activity.
Citation Format: Fernández-Calienes A, Fraga J, Mendiola J, Scull R, Morier L, Linares R, Mendoza D, Cuéllar A (2015) Anti-plasmodial activity of Parthenium hysterophorus L. lactones. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S47. Abstract nr OC-28.