OC-39: MANGIFERIN: THE CHALLENGE OF TRANSFORM A NATURAL ANTIOXIDANT WITH AN EXCELENT PRECLINICAL PHARMACOLOGICAL PROFILE IN NEW PHARMACEUTICAL PRODUCTS

J Pharm Pharmacogn Res 3(suppl. 1): S57, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Oral Communication

OC-39: MANGIFERIN: THE CHALLENGE OF TRANSFORM A NATURAL ANTIOXIDANT WITH AN EXCELENT PRECLINICAL PHARMACOLOGICAL PROFILE IN NEW PHARMACEUTICAL PRODUCTS

Delgado R1, Garrido B1, Hernández I2, Rodeiro I2, Romero JA1, Rodríguez JC1, Quiñones OL1, Acosta J3, Nuevas L1, Salomón S1, Rodríguez C1, Haegeman G4, Vanden Berghe W5.

1Center for Pharmaceutical Research and Drug Development, Ave 26 e/ Ave 51 and Boyeros, Havana, Cuba. E-mail: rdelgado@infomed.sld.cu
2Laboratorio de Farmacologia. Center of Marine Bioproducts (CEBIMAR), La Habana, Cuba.
3Facultad de Química, ISPJAE, La Habana, Cuba.
4Laboratory of Eukaryotic Gene Expression and Signal Transduction (LEGEST), Department of Physiology, Ghent University, K.L. Ledeganckstraat 35, B-9000 Gent, Belgium.
5Laboratory of Protein Science, Proteomics and Epigenetic Signaling (PPES), Department of Biomedical Sciences, University Antwerp, Campus Drie Eiken, Universiteitsplein 1, Wilrijk, Belgium.

 

Mangiferin (M) is a very interesting glucosilxanthone, which has been known for its antioxidant, immunomodulatory, antitumoral and anti-inflammatory actions. Precedent investigations showed the results of studies realized with an extract obtained from stem bark and leaves of Mangifera indica L. were mangiferin represent the major bioactive component. In general, mangiferin as active ingredient in Vimang extract and in others natural extract or as compound isolated from different sources, represent an important natural compound with potentialities for pharmaceutical formulations against cancer and anti-inflammatory actions. We studies have demonstrated that mangiferin as a natural xanthone present antiangiogenic activities and these properties could be pharmacological relevant for its use of treatment of some tumors where neovascularization result essentially for the development of the malignance process. Our projects have been orientated for to future development of new phytopharmaceutical drug with mangiferin as active ingredient in different pharmaceutical formulations. Financial Support: VLIR UOS programme Nr. ZEIN2011PR383 and a National project of CIDEM.

 

Citation Format: Delgado R, Garrido B, Hernández I, Rodeiro I, Romero JA, Rodríguez JC, Quiñones OL, Acosta J, Nuevas L, Salomón S, Rodríguez C, Haegeman G, Vanden Berghe W (2015) Mangiferin: the challenge of transform a natural antioxidant with an excelent preclinical pharmacological profile in new pharmaceutical products. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S57. Abstract nr OC-39.