J Pharm Pharmacogn Res 3(suppl. 1): S64, 2015
Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.
OC-46: Rhopalurus junceus SCORPION VENOM: ANTITUMORAL, ANTIMETASTATIC EFFECT AND MECHANISM OF ACTION AGAINST EPITHELIAL CANCER
Díaz-García A1, Yglesias A1, Ruiz-Fuentes JL2, Rodríguez H2, Rodríguez L1.
In Cuba, the venom from the endemic scorpion Rhopalurus junceus has been used, in the traditional medicine, for anticancer treatment. Recently the potentialities of this scorpion have been identified in studies in vitro and in vivo as antitumoral. The mechanisms of action of the scorpion venom have been not been described for this species. The antitumoral and antimetastatic effect is executed against tumor from epithelial origin. The natural extract at low concentrations induces the cellular death through apoptosis, which include the increase of the expression levels of apoptotic genes as well as the decrease of level expression of anti-apoptotic genes, loss of mitochondrial membrane potential, and DNA nuclear fragmentation while at higher concentration is capable of inducing necrosis. The mechanism of action of the scorpion venom involves the affectation to the functional activity of ionic channels related to the proliferation and metastatic process in epithelial cancer cells. Besides, the scorpion venom induces the affectation of the cellular signalling pathways PI3K and MAPK. The peptides present in the scorpion venom represent the active components responsible for the anticancer effect. The antitumoral effect, biodistribution and localization of peptides, in mice, corroborate the cytotoxicity and high selectivity against tumor cells from solid tissue. All these evidences confirm the anticancer therapeutic potential of the scorpion venom against cancer and the possibility of obtaining the peptides through recombinant and biotechnological techniques.
Citation Format: Díaz-García A, Yglesias A, Ruiz-Fuentes JL, Rodríguez H, Rodríguez L (2015) Rhopalurus junceus scorpion venom: antitumoral, antimetastatic effect and mechanism of action against epithelial cancer. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S64. Abstract nr OC-46.