OC-53: IMMUNEREGULATORY PHENOTYPE SHIFT BY BEE Apis ACCUPUNCTURE IN PRIMARY PROGRESIVE MULTIPLE SCLEROSIS

J Pharm Pharmacogn Res 3(suppl. 1): S76, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Oral Communication

OC-53: IMMUNEREGULATORY PHENOTYPE SHIFT BY BEE Apis ACCUPUNCTURE IN PRIMARY PROGRESIVE MULTIPLE SCLEROSIS (PPMS)

Abuín A, Fernández F, Milián L, Rodríguez Y.

Matanzas Medical Science University, Cuba. E-mail: alfredoabuin.mtz@infomed.sld.cu  tel. 52836049.

 

Introduction: Apitherapy has been used to immunological chronic disease treatment. We present a PPMS case report with cognitive and evidence based medicine focus. Objective: Show clinical, biochemical, chronobiological and immunological state changes before and after apipunctural treatment in PPMS. Methods: Beeapipuncture were made two times a week as evidence and cognitive in individual focus selected points. The clinical evolution was assessed by comparing the related significant symptom scale in Multiple Sclerosis Ross Test, which explores 15 aspects of the affective, conative, and volitional spheres. Biochemical clasics varibles were analyzed. Chronobiological changes tested by means of tow points circadian temperature cycle, and Immunological status by ESR and cytokine pattern change. Results: Ross test score items for integrity clinical function increased, shows an improvement in the neurological condition. The functions more improved were: balance, bowel control, muscle strength in the upper limbs and mood. No significant differences in biochemical variables, only a slight decrease in triglycerides, demonstrating the therapeutic safety of apipuncture. There is an increase in the robustness of circadian temperature rhythm. We found a displacement from proinflammatory Th1 and Th17 phenotypes towards Th2-ThF regulatory phenotype in CD4 lineage after apitherapy. So suggests an improvement to more competent state in the immune system and less reactive behavior. Conclusions: Apipuncture show effective and safety in PPMS.

Citation Format: Abuín A, Fernández F, Milián L, Rodríguez Y (2015) Immuneregulatory phenotype shift by bee Apis accupuncture in primary progresive multiple sclerosis (PPMS). [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S76. Abstract nr OC-53.