J Pharm Pharmacogn Res 3(suppl. 1): S21, 2015
Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.
OC-60: A MULTIFACTORIAL APPROACH FOR ANTIPLATELET DRUG DISCOVERY FROM MEDICINAL PLANTS
Introduction: Antiplatelet drugs are prescribed to prevent atherothrombotic diseases. However, the efficacy of currently available drugs is limited. Therefore, new therapeutic options are needed. Antithrombotic agents could be developed from herbs. Nevertheless, “antiplatelet” is not a popular term. Therefore, a research strategy is necessary for this purpose. Some evidence could provide a scientific support for it. For instance, chemical structure- antiplatelet activity relationships have demonstrated the importance of hydroxyl groups, therefore, the presence of metabolites bearing this functional group like flavonoids could provide plant product with an antiplatelet potential. On the other hand, other biological activities that are related with the inhibition of platelet activation could guide the selection of plant species to be evaluated. Material and Methods: Extracts from five botanical species (Citrus aurantifolia Ch, Citrus aurantium L, Citrus sinensis L., Morinda citrifolia L. and Wendita calysina Griseb.) were included in a screening of antiplatelet potentials. Plant products effects on platelet aggregation (PA) was assessed against adenosine diphosphate (ADP)-, collagen-, epinephrine- and arachidonic acid- induced stimulation of human plasma in vitro and/or against ADP- induced activation of rat plasma ex vivo. Common characteristics of herb-derivate platelet inhibitors (traditional use, other biological properties and major secondary metabolites) were also analyzed. Results: All plant preparations, except A aurantium fruit peel extract and M citrifolia juice, showed inhibitory effects in vitro and or ex vivo . Traditional uses for fever, inflammation, bronchitis, bronchial asthma and / or vascular disorders; as well as antioxidant and anti-inflammatory pharmacological properties were characteristic features of these species. Conclusions: The results suggest that ethnomedical, pharmacological and chemical information about medicinal plants could be useful for antiplatelet drugs discovery from medicinal plants.
Citation Format: García M (2015) A multifactorial approach for antiplatelet drug discovery from medicinal plants. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S21. Abstract nr OC-60.