OC-64: PHARMACOLOGICAL ACTIVITIES OF PROTEOLYTIC Vasconcellea LATEX FRACTION PAPAYA

J Pharm Pharmacogn Res 3(suppl. 1): S67, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Oral Communication

OC-64: PHARMACOLOGICAL ACTIVITIES OF PROTEOLYTIC Vasconcellea LATEX FRACTION PAPAYA

Salas CE.

Institute of Biologycal Science, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. E-mail: cesbufmg@yahoo.com

 

The lactiferous species Vasconcellea cundinamarcensis (ex Carica candamarcensis) is native to Latin America and belongs to the Caricaceae family. Members of this family possess a set of isomorphous proteolytic enzymes in their lattices whose role has been associated with plant protection against predation. We can imagine that plant latex plays a role akin to blood in mammalian circulatory system. Some of the proteinases present in V. cundinamarcensis display mitogenic activity in mammalian cells, which set the basis to study their potential as healing agents. The results confirmed the healing effect in various animal ulcer models including humans and a mechanism was proposed to explain the healing stimulus. More recent studies show that these latex proteinases are immunomodulatory, anti-inflammatory, dissolve thrombus and display antitumor/antimetastasic activity. We currently develop a phase II clinical study to validate the healing effect of a formulation containing the proteolytic fraction in individuals bearing recalcitrant lesions. An overview of the results obtained is discussed in this presentation.

 

Citation Format: Salas CE (2015) Pharmacological activities of proteolytic Vasconcellea latex fraction papaya. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S67. Abstract nr OC-64.