OC-65: SAFFRON-BASED BIOACTIVE MOLECULE “CROCIN” PREVENTS LIVER CANCER

J Pharm Pharmacogn Res 3(suppl. 1): S68, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Oral Communication

OC-65: SAFFRON-BASED BIOACTIVE MOLECULE “CROCIN” PREVENTS LIVER CANCER

Amin A.

Biology Department, UAE University, P.O. Box 15551, Al-Ain, UAE, Off: +9713-7136519, Fax: +9713-134927. E-mail: a.amin@uaeu.ac.ae

 

Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death worldwide. The prognosis of patients with HCC is usually poor; hence, a novel approach against HCC is essential for a better therapeutic outcome. Saffron and its active constituents were reported to have antioxidant, anti-inflammatory, and anti-tumor properties. The aim of this study was to investigate chemopreventive action of crocin, one of the promising active constituents of saffron, against diethylnitrosamine (DEN)-induced liver cancer in rats, and the possible mechanisms by which crocin exerts its anti-tumor effects. Findings reported herein demonstrated the anti-proliferative and pro-apoptotic properties of crocin when administrated in DEN-treated rats. Additionally, crocin exhibited anti-inflammatory properties that inhibited NF-kB, among other inflammatory markers. Taken together, our findings introduce crocin as a potent chemopreventive and therapeutic agent against HCC.

 

Citation Format: Amin A (2015) Saffron-based bioactive molecule "crocin" prevents liver cancer. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S68. Abstract nr OC-65.