J Pharm Pharmacogn Res 3(suppl. 1): S88, 2015
Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.
OC-76: NEUROPROTECTIVE COMPOUNDS FROM MACROALGAE: IMPLICATIONS FOR NEURODEGENERATIVE DISEASES
Menéndez R, García T, Morales RA, Valdés O, González K, Hernández Y.
Marine environment has proven to be a rich source of novel and diverse compounds with numerous interesting biological effects. Macroalga are currently being explored for searching these novel bioactive compounds whose therapeutic potential has been assessed in a variety of animal models. There is an increasing prevalence of different forms of dementia worldwide and therefore, researchers have been focusing their attention on the discovery and development of new compounds with potential application in the amelioration of cognitive dysfunction. Cognitive disorders, including neurodegenerative diseases such as Alzheimer’s disease (AD) and other memory related disorders are characterized by progressive neurodegeneration triggered by neuro-inflammation, oxidative/nitrosative damage and synaptic loss. Therefore, compounds exerting neuroprotective action could present an approach in the management of dementia. In fact, several studies had already provided promising insights into the neuroprotective effects from different macroalgae species. The objective of this review is to provide an overview on these results and those obtained in our center and their potential application to treat and/or prevent memory disorders.
Citation Format: Menéndez R, García T, Morales RA, Valdés O, González K, Hernández Y (2015) Neuroprotective compounds from macroalgae: implications for neurodegenerative diseases. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S88. Abstract nr OC-76.