J Pharm Pharmacogn Res 3(suppl. 1): S91, 2015
Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.
OC-79: NEUROPROTECTIVE EFFECT OF PHYCOCYANOBILIN EXTRACTED FROM Spirulina platensis
Piniella B, Pentón G, Campos R.
Introduction: Although the huge economic and social impact and the predicted incidence increase, neuroprotection for ischemic stroke remains as a therapeutically empty niche. The C-phycocyanin is a natural compound, a biliprotein, found in some blue-green algae such as Spirulina platensis. C-phycocyanin has previously been shown to have strong antioxidant, anti-inflammatory, and neuroprotective actions. Its structure consists of two polypeptide chains (α and β), which have attached a tetrapyrrole compound, denominated phycocyanobilin. To administer C-phycocyanin in vivo, it is digested and releases the phycocyanobilin. In the present study, we investigated the rationale of the phycocyanobilin treatment focal cerebral ischemia/reperfusion (I/R) injury in rats. Methods: In this study, Wistar rats were injured with endothelin-1 intracerebrally with perforation of skull and inserting an injection needle. Treatment was applied intraperitoneally with cumulative doses of phycocyanobilin 50, 100, 200 µg/kg at 30 min, 1, 3, and 6 h post-surgery. After 48 h, the neurological examination was performed and 24 h later the cerebral infarct volume was determined. Results: The post-ischemic phycocyanobilin treatment was able to improve the clinical status and significantly reduced the volume of brain stroke, according to the results obtained with the neurological evaluation. Phycocyanobilin is able to penetrate the blood-brain barrier and enters the brain parenchyma, where they exert pharmacological actions such as antioxidants. Conclusions: In our study, a neuroprotective effect of phycocyanobilin was demonstrated in animal models of I/R brain in rats.
Citation Format: Piniella B, Pentón G, Campos R (2015) Neuroprotective effect of phycocyanobilin extracted from Spirulina platensis. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S91. Abstract nr OC-79.