OC-81: EVALUATION OF PHARMACOLOGICAL SCREENING AND TOXICITY PROFILE OF SELECTED HOMEOPATHIC DRUGS

J Pharm Pharmacogn Res 3(suppl. 1): S25, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Oral Communication

OC-81: EVALUATION OF PHARMACOLOGICAL SCREENING AND TOXICITY PROFILE OF SELECTED HOMEOPATHIC DRUGS

Singh S1, Gupta P2, Khurana A3, Gupta YK1, Manchanda R3.

1Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
2Central Research Institute for Homoeopathy, Noida, India. E-mail: pankajgupta77@gmail.com
3Central Council for Research in Homoeopathy, New Delhi, India.

 

Aim: Present study was carried out to evaluated pharmacological efficacy and toxicity testing of three homeopathic drugs viz. Ferrum phos. (3X & 6X), Calcarea Phos (6X) and Magnesium Phos (6X). Material and Methods: The study was divided into two parts. Pharmacological efficacy, as anti-analgesic, anti-inflammatory and anti-arthritic activity of drugs were evaluated in first part of the study. The pharmacological models employed included, eddy’s hot plate induced thermal algesia, carrageenan-induced paw edema and complete freund’s adjuvant-induced arthritis in rats. Study was carried out in male Wistar rats with 14mg/kg of drug dose administered orally. In the second part, acute, sub-acute (28 days) and chronic (180 days) toxicity testing of drugs was carried out as per respective OECD guidelines. Results and Conclusions: Ferrum Phos 6X established significant anti-inflammatory activity exhibiting 28% percentage inhibition, which was comparable to standard drug indomethacin (38%). Further, a significant anti-analgesic activity was also demonstrated by ferrum phos 6X. However, Ferrum Phos in 3X potency, Calcarea phos and Magnesium Phos showed little or no efficacy in all the pharmacological models screened. All these homeopathic drugs shared a safe toxicity profile at dose up to 2000mg/kg body weight.

Citation Format: Singh S, Gupta P, Khurana A, Gupta YK, Manchanda R (2015) Evaluation of pharmacological screening and toxicity profile of selected homeopathic drugs. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S25. Abstract nr OC-81.