J Pharm Pharmacogn Res 3(suppl. 1): S140, 2015
Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.
PCT-48: BENEFICIAL EFFECTS OF A ROSE-HIP PRAPARATION CONTAINING SEEDS AND SHELLS ON AGING AND WRINKLES OF THE SKIN
Petharat L1, Wongsuphasawat K1, Winther K2.
Objectives: To evaluate the effects of Rose-hip powder (LiTo) from Langeland, Denmark, on cell senescence and skin wrinkling. Material and Methods: A total of 34 healthy subjects, aged 35-65 years with wrinkles of the face (crow’s feet) were subjected to a randomized and double-blinded clinical study of the effects of the Rose-hip powder as compared to a well established facial skin modifier, astaxanthin. Half of the study participants ingested LiTo rose hip (3 g daily) for 8 weeks, while the other half were administered 4 mg of astaxanthin, twice daily for the same period of time. Objective measurements of wrinkles, skin moisture and elasticity were made by using visioscan, corneometer and cutometer at the beginning of the study and after eight weeks. The effect of LiTo on cell longevity was measured in terms of leakage of hemoglobin through red cell membranes (hemolytic index) in blood samples kept in a blood bank for 5 weeks. The test blood samples used here were collected from 17 healthy subjects aged 30 – 59 years, who had been administered LiTo (45g daily) for 4 weeks. Significance was attained with p≤0.05. Results: In the double blinded study, the Rose-hip group showed statistically significant improvements in crow’s feet wrinkles (p<0.034), skin moisture (p<0.003) and elasticity (p<0.039) after 8 weeks of treatment. A similar improvement was observed for astaxanthin, with p values: 0.003, 0.001 and 0.014 respectively. Hence, there was no overall significant difference in effectiveness when comparing the present rose-hip powder and astaxanthin group. Both treatments reduced wrinkles of the skin. LiTo rose hip powder also reduced the leaking of haemoglobin through erythrocyte membranes. Conclusions: It is suggested that the present Rose-hip powder aliviates wrinkles and some elements of aging through mechanisms involving collagen, anti-oxidants and particular fatty acids.
Citation Format: Petharat L, Wongsuphasawat K, Winther K (2015) Beneficial effects of a rose-hip praparation containing seeds and shells on aging and wrinkles of the skin. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S140. Abstract nr PCT-48.