PNAI-34: ANTIMICROBIAL ACTIVITY OF LEAF EXTRACTS OF Moringa oleifera

J Pharm Pharmacogn Res 3(suppl. 1): S126, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Poster

PNAI-34: ANTIMICROBIAL ACTIVITY OF LEAF EXTRACTS OF Moringa oleifera

Echemendía O, Callico A, Lago V, Almora E, Bolaños G, Fidalgo O, Monteagudo R, Morales Y.

Instituto Finlay. Ave 27 No.19805, La Lisa, Ap.16017. Cod. 11600. La Habana, Cuba. Teléfono: 7271 8177 extensión 156. E-mail: oalicia@finlay.edu.cu

 

Introduction: Many natural products possess antibacterial activity which can be used as therapeutic alternative due to the emergence of antimicrobial resistance. Moringa oleifera Lam plant native to the India, use as food, water treatment and traditional medicine. Moringa also has other properties like anti-inflammatory, antimicrobial, antioxidant, anticancer, cardiovascular, hepatoprotective, anti-ulcer, and diuretic activities. Objective: The aim of the present study was to evaluate the antimicrobial activity of alcoholic and aqueous  extracts leaf from of three variants of Moringa oleifera (criolla, plain, supergenius) against of the references strains Escherichia coli (ATCC10536), Staphylococcus aureus (ATCC 6538), Candida albicans (ATCC 10231), Pseudomonas aeruginosa (ATCC9027), Salmonella thyphi (9992v), Vibrio cholerae (C7258) and microorganisms isolated from clinical samples. Material and Methods: The antimicrobial activity was determinated for microdilution plating method for determining the Minimum Concentration Lethal (MCL) according the National Committee for Clinical Laboratory Standar (NCCLS). The microorganisms were adjusted with the turbidity standard McFarland 0.5. Two-fold dilutions of the extracts were prepared from concentrations 100 mg/mL until 0.78 mg/mL. Results: The alcoholic extract 70% of criolla variant exhibited the strongest antimicrobial activity against the studied bacterial and yeast strains, with CML 3.1 mg/mL to 5.8 mg/mL. The alcoholic extracts of plain variant showed a weak to moderate activity against the tested microrganisms. The antimicrobial activity of aqueous extracts of the three variants was generally low. Conclusions: Moringa oleifera extracts possess good antimicrobial activity and could be used as source for new therapeutic treatment of infections caused by these infectious agents.

 

Citation Format: Echemendía O, Callico A, Lago V, Almora E, Bolaños G, Fidalgo O, Monteagudo R, Morales Y (2015) Antimicrobial activity of leaf extracts of Moringa oleífera. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S126. Abstract nr PNAI-34.