POS-90: A HERBAL REMEDY MADE FROM Rosa canina SUBSPECIES LITO ACT AS AN ANTI-INFLAMATORY AGENT IN HORSES EXPOSED TO STRENOUS EXERCISE

J Pharm Pharmacogn Res 3(suppl. 1): S183, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Poster

POS-90: A HERBAL REMEDY MADE FROM Rosa canina SUBSPECIES LITO ACT AS AN ANTI-INFLAMATORY AGENT IN HORSES EXPOSED TO STRENOUS EXERCISE

Winther K1, Kharazmi A2, Hansen P1.

1Department of Nutrition, Exercise and Sport, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark. E-mail: kaha@nexs.ku.dk
2Department of Clinical Microbiology, Rigshospitalet, University of Copenhagen, Denmark.

 

Objectives: A standardized rose-hip powder containing seeds and shells from subspecies LiTo has shown anti-inflammatory properties and improves flexibility and reduces pain in humans suffering from osteoarthritis. A galactolipid GOPO with strong anti-inflammatory and anti-oxidative properties was recently isolated from the product. The same remedy has been proven effective also in dogs. The present study aimed to test if the powder would improve the immune system and working capacity in horses exposed to strenuous exercise. Material and Methods: Seventyfour horses, all trotters, which often develop osteoarthritis early in their life due to intensive training and performance in an oval track were included in a double-blind placebo controlled trial. Horses were randomly allocated to either LiTo rose hip powder (210 g daily added to their food) or placebo powder for a three-month period. The anti-inflammatory capacity was estimated as chemotaxis of peripheral blood neutrophils using a Boyden Chamber and the anti-oxidative capacity by using chemiluminescence and by measuring vitamin C levels in plasma. The working capacity was estimated by counting the seconds used to run a 1000 meter and the behavior was evaluated by questionnaires answered by the staff taking care of the horses. Results: During active treatment, chemotaxis significantly declined indicating enhanced anti-inflammatory activity and the anti-oxidative capacity significantly rose. No such change was observed during placebo treatment. Horses on active treatment shortened their time to run a 1000 meter with 1.1 ± 1.5 s (p<0.02). The horses on placebo slightly increased their time to run the same distance. It was reported from questionnaires that horses were more lithe and easier to work with the day after strenuous exercise when on the present active treatment. Conclusions: The present data suggest that powdered rose hip from subspecies LiTo works as an anti-inflammatory agent in horses and improves the working capacity.

Citation Format: Winther K, Kharazmi A, Hansen P (2015) A herbal remedy made from Rosa canina subspecies lito act as an anti-inflamatory agent in horses exposed to strenous exercise. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S183. Abstract nr POS-90.