POS-91: ULTRASOUND ASSISTED EXTRACTION OF FLAVONOIDS FROM LEAVES OF Annona muricata L.

J Pharm Pharmacogn Res 3(suppl. 1): S184, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Poster

POS-91: ULTRASOUND ASSISTED EXTRACTION OF FLAVONOIDS FROM LEAVES OF Annona muricata L.

Sevilla I1, Rodríguez E1, Henry Y2, Acosta J1, Salomón S3.

1Instituto Superior Politécnico José A. Echevarría. Calle 114, # 11901, e/ Ciclovía y Rotonda, Marianao, La Habana, Cuba. E-mail: isevilla@quimica.cujae.edu.cu
2Grupo Empresarial Labiofam, Ave. Independencia, Km 16 ½, Boyeros, La Habana, Cuba.
3Centro de Investigación y Desarrollo de Medicamentos (CIDEM), 26 y 51, Plaza, La Habana, Cuba.

 

Introduction: Annona muricata L. is a native tree of Mexico and the Caribbean, widely spread at the tropical regions of America, Asia and Africa. It has used, for years, for the treatment of many diseases due to its anticancerous, bactericide, antitumoral and antidiabetic properties. Flavonoids are one of the composed bioactive groups more studied due to its anticancerous and antiviral properties. The ultrasound assisted extraction as nonconventional method of extraction is important for the rapidity and efficiency in phytoconstituents obtaining, in comparison with the traditional methods of extraction. Material and Methods: The influence of operation parameters was evaluated (time of extraction, concentration of ethanol and solvent/vegetal material relation), in flavonoids extraction from A. muricata leaves, by ultrasound. An orthogonal experimental design was used and the results were compared with the method of extraction by stirred tank. Results: The best conditions for the extraction are: time of 2.5 h, 90% of ethanol concentration and solvent/vegetal material ratio of 53 mL/g, for an optimal value of yield of flavonoids of 0.321 ± 0,003 mg/g. In the comparison between the ultrasound-assisted extraction (UAE) and the stirred tank methods, was obtaining as result that time in the last one was 0.7 times shorter than when the work is done by UAE. Nevertheless, the flavonoids amount is 1.8 times greater in UAE. Conclusions: The method of extraction by ultrasound is more efficiency than stirred tank.

 

Citation Format: Sevilla I, Rodríguez E, Henry Y, Acosta J, Salomón S (2015) Ultrasound assisted extraction of flavonoids from leaves of Annona muricata L. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S184. Abstract nr POS-91.