POS-95: PREFORMULATION STUDY OF A MOUTHWASH WITH Salvia officinalis L.

J Pharm Pharmacogn Res 3(suppl. 1): S188, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Poster

POS-95: PREFORMULATION STUDY OF A MOUTHWASH WITH Salvia officinalis L. (CASTILE SAGE)

Ortiz Y, Ramos K, Lahera M, Moreno O, Martínez H.

University of Medical Sciences of Granma. Branch Bayamo. Carretera central vía Santiago de Cuba. S/N. Bayamo, Granma, Cuba. E-mail: yurisnel.grm@infomed.sld.cu

 

Introduction: The ethnomedical use of Salvia officinalis L. has been reported as antiseptic, disinfectant and anti-inflammatory. Due to these properties, the Medical Specialties Regulation recommends it to be used in Phytopharmacology and Apipharmacology as an object of revision, widening and improvement on account of the practical experiences obtained after its application and future investigations, because of the low availability of herbal products to treat otolaryngological complaints that bring about hoarseness, cough, rhinitis, pharyngeal inflammation and pain; on the other hand, the plant´s fluid extract and its tincture is too unpleasant to be used in gargling. It was decided to elaborate a mouthwash using the fluid extract of this plant. Methods: An experimental study of preformulation of a mouthwash was done. In a first stage, the components, elaboration way and the dosage of the active principle were selected. Then a mouthwash was elaborated, the physical, chemical and microbiological (organic-leptonic properties, pH, density, total solids, refraction index and microbiological stability) parameters were determined and evaluated taking into account the time. The data were statistically processed analyzing the variance for repeated measurements (ANOVA) to carry out the standardization of the measured parameters, establishing the intervals of confidence (95%) to a significance level minor than 0.05. Results: It was determined the physical-chemical and microbiological stability concerning the three lots that were elaborated in 0, 3 and 6 months. The product presented an acceptable appearance, with a pleasant smell and flavor, statistically showing a significant variation only of the pH starting from the third month. Conclusions: The formulation turned out to be physical-chemical and microbiologically stable in the container and the storing conditions where was studied, proposing the expiration date at the third month in room temperature.

 

Citation Format: Ortiz Y, Ramos K, Lahera M, Moreno O, Martínez H (2015) Preformulation study of a mouthwash with Salvia officinalis L. (Castile sage). [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S188. Abstract nr POS-95.