J Pharm Pharmacogn Res 3(suppl. 1): S98, 2015
Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.
PPP-06: DIRECT ACTIONS OF FLAVONOIDS ON RAT CARDIAC MUSCLE
Fleites A, Galán L, Herrera I, Alvarez JL.
Introduction: Flavonoids are a class of natural polyphenolics that are ubiquitous in plants, vegetables, fruits, and beverages of plant origin, such as tea and wine. Numerous prospective epidemiological studies have found beneficial effects of flavonoid consumption on overall cardiovascular mortality. Conventionally, these beneficial effects have been attributed primarily to nonspecific antioxidant and antithrombotic properties of flavonoids, however little is known about actions of flavonoids on cardiac muscle. Aims: To evaluate the effects of three flavonoids (naringenin, quercetin and genistein) on the surface electrogram (ECG) and the force of contraction (FC) of rat hearts. Material and Methods: ECG and FC were recorded on rat hearts perfused in a Langendorff column Results: Only genistein from studied flavonoids tended to prolong the QT interval of ECG in concentration dependent manner. None of flavonoids had any action on the QRS interval or the RR of ECG. Genistein and naringenin produced a negative inotropic effect on the entire range of concentrations studied; they decreased FC with an IC50 of 8.4 μM and 0.5 μM, respectively. Quercetin at low concentrations had a positive inotropic effect and negative inotropic effect at high concentrations. Conclusions: The results indicate that these flavonoids have direct actions on rat cardiac muscle. These actions should be taken into account when considering these molecules either as dietetic supplements or as templates to develop therapeutic agents for human diseases.
Citation Format: Fleites A, Galán L, Herrera I, Alvarez JL (2015) Direct actions of flavonoids on rat cardiac muscle. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S98. Abstract nr PPP-06.