J Pharm Pharmacogn Res 3(suppl. 1): S99, 2015
Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.
PPP-07: In vivo ANTI-INFLAMMATORY ACTIVITY OF EXTRACTS, FRACTIONS AND ISOLATED COMPOUNDS OF Tabebuia spp.
Regalado AI1, Sánchez LM1, Mancebo B1, Flogio MA2.
Introduction: Inflammation is a defense mechanism of the body and occurs against harmful stimuli; however, the extension may cause damage to cells and tissues. Chronic inflammatory diseases are a major health problem due to the lack of effective and safe drugs for use for long periods; this has augmented the investigations to provide new safer anti-inflammatory agents. Throughout history, nature, especially plants, has provided a source of medicines for the treatment of a wide spectrum of diseases. Tabebuia spp. is an endemic plant of Cuba, unexplored from the standpoint chemist-pharmacologic. Material and Methods: This research was conducted in order to assess the possible anti-inflammatory effect of this species using the carrageenin-induced paw edema models and the croton oil induced auricular edema in mice. Results: The methanolic extract of the leaves has no anti-inflammatory effect in the dose evaluated, whereas the methanolic extract of the stems showed an anti-inflammatory activity at dose of 500 mg/kg relative to the negative control group. Subsequently, the fractionation of the methanolic extract of the stems and pharmacological evaluation of these fractions is conducted, where ethyl acetate-methanol fraction was the most active. Moreover, it was possible to isolate a compound in ether-petroleum ethyl acetate fraction, it proved to be the majority in the stems, with an anti-inflammatory activity similar to indomethacin used as a positive control. Conclusions: The results of this research demonstrate the anti-inflammatory activity from Tabebuia spp stems, constituting the first preclinical report of anti-inflammatory effect in the species. Tabebuia spp. and their constituents could represent in the future a new therapeutic option for the treatment of inflammatory diseases.
Citation Format: Regalado AI, Sánchez LM, Mancebo B, Flogio MA (2015) In vivo anti-inflammatory activity of extracts, fractions and isolated compounds of Tabebuia spp. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S99. Abstract nr PPP-07.