PPP-12: EVALUATION OF THE ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF Mosiera bullata LEAVES

J Pharm Pharmacogn Res 3(suppl. 1): S104, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Poster

PPP-12: EVALUATION OF THE ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF Mosiera bullata LEAVES

Vicet-Muro L, Armas-González Y, Siverio-Mota D, Sueiro-Oyarsun M, Ribalta-Ribalta V1, Concepción-Marrero G, Fuentes-Valdés M.

Department of Pharmacy. Faculty of Chemistry-Pharmacy, Universidad Central “Marta Abreu” de Las Villas, Santa Clara 54830, Villa Clara, Cuba. E-mail: lill@uclv.edu.cu

 

Introduction: Mosiera bullata (Britton & P. Wilson) Bisse is an endemic Cuban plant, which belongs to the family Myrtaceae. Its use in Natural Medicine is unknown, but phytochemical screenings suggest that this species has potential as an anti-inflammatory drug. Objective: Considering the importance in the search for bioactive molecules from medicinal plant the aim of this study was to evaluate of probable anti-inflammatory and antinociceptive effects of an ethanolic extract of Mosiera bullata. Methods: Dried powder of leaves of M. bullata was exhaustively extracted with (80%) ethanol.  The resulting M. bullata ethanol extract (MBEE) was investigated in acute model of inflammation by carrageenan-induced paw edema model in rats and topical edema induced by TPA (12-0-tetradecanoylphorbol acetate) in the mouse ear. Additionally, the analgesic activity was evaluated in writhings induced by acetic acid in mice. Total phenolic compounds were determinated spectrophotometrically using Folin-Ciocalteu reagent and the results are expressed as galic acid equivalents per gram dry weight. Results: The extract (1 mg/ear) inhibited significantly (P<0.05) topical edema induced by TPA and its activity (97.43%) was statistically comparable with indomethacin inhibition (98.18%). In the systemic edema of the rat paw, the ethanol extract (MBEE) (400 mg/kg b.w) significantly (P<0.05) suppressed the development of paw edema induced by carrageenan. Its activity, at 3 h post administration of carrageenan, (54.60%) was higher than  ibuprofen (47.23%) and diclofenac (44.71%) but lower than indomethacin inhibition (%) oral administration of the ethanol extract (MBEE) reduced significantly (P<0.05) the number of writhings induced by acetic acid. The presence of total phenols (246.80 mg GAE/g DW) can be related to its anti-inflammatory and analgesic properties showed for the evaluated extract. Conclusions: Our results suggest that (80%) ethanol extract of leaves of Mosiera bullata possess significant anti-inflammatory and analgesic properties, consequently, it could be a new source for natural products.

Citation Format: Vicet-Muro L, Armas-González Y, Siverio-Mota D, Sueiro-Oyarsun M, Ribalta-Ribalta V, Concepción-Marrero G, Fuentes-Valdés M (2015) Evaluation of the anti-inflammatory and analgesic activities of Mosiera bullata leaves. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S104. Abstract nr PPP-12.