J Pharm Pharmacogn Res 3(suppl. 1): S107, 2015
Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.
PPP-15: PHARMACOLOGYCAL AND TOXICOLOGYCAL ACTIVITY OF AQUEOUS EXTRACT OF Solanum torvum
Pérez L, Puente E, Fong O, Salas H, Cedeño N, Wawoe N, Larramendi D, Barreiro AV.
Introduction: The medicinal plants contain active principles that although they are those responsible for the therapeutic properties that are attributed. Objectives: to evaluate the anti-inflammatory activity, acute oral toxicity for the method of the classes and the toxicity to repeated dose of the aqueous extract of leaves and shafts of Solanum torvum in Sprague Dawley rats. Methods: was carried out a test of anti-inflammatory activity for the method of formalin to 1%, a test of acute oral toxicity for the method of the classes, toxicity assay was realized by the repeated doses method (Limit Test) during 28 days. The anti-inflammatory activity of the extract was evaluated respectively in three experimental groups that they received unique administrations from the product to the dose levels of 600, 300 and 150 mg/kg, using the positive controls indomethacine and Ibuprofeno. The administration in the toxicological acute evaluation was made to unique dose of 2 000 mg/kg, and 1 000 mg/kg, in the case of the toxicity by the repeated doses method. Anatomopathology, histology, hematolo-gy and biochemist blood studies were made. Results: The study result shows that the aqueous extract of the Solanum torvum plant in a 600 mg/kg dose inhibits inflammation at a 72.03 %, without altering the clinical and physiological parameters; macroscopically they were not proven alterations of diagnostic value. Conclusions: The extract test exhibits anti-inflammatory properties in the animal pattern and dose level used under the experimental conditions, the aftermath of the study did not evidence signs of toxicity in the experimental model.
Citation Format: Pérez L, Puente E, Fong O, Salas H, Cedeño N, Wawoe N, Larramendi D, Barreiro AV (2015) Pharmacologycal and toxicologycal activity of aqueous extract of Solanum torvum. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S107. Abstract nr PPP-15.