PPP-16: PRECLINICAL EVALUATION OF ANTINFLAMATORY AND GASTROPROTECTIVE ACTIVITY OF THE LIQUID EXTRACT FROM THE LEAVES OF Capraria biflora L.

J Pharm Pharmacogn Res 3(suppl. 1): S108, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Poster

PPP-16: PRECLINICAL EVALUATION OF ANTINFLAMATORY AND GASTROPROTECTIVE ACTIVITY OF THE LIQUID EXTRACT FROM THE LEAVES OF Capraria biflora L.

Valido-Díaz A1, Vicet-Muro L2, Boffill-Cárdenaz M3, Pizarro-Espín A1, Valdés-Álvarez M1, Blanco Machado F1.

1Experimental Toxicology Unit. Villa Clara Medical College. Cuba. E-mail: lill@uclv.edu.cu
2Chemistry – Pharmacy Faculty. Central University “Marta Abreu” de Las Villas, Cuba.
3Medicine Faculty. Villa Clara´ Medical College, Cuba.

 

Introduction: Capraria biflora L, belongs to the family Schrophulareaceae. It´s a plant with a long history in traditional medicine, commonly used in chronic pathologies associated to inflammatory processes. Objective: In this current study, it has been proofed for the first time through experimental techniques, its antinflamatory and gastoprotective effects in chronic events of a liquid extract obtained from the leaves of this plant. Methods: For the study of its anti-inflammatory effects was put into practice the model of chronic inflammation of granulomas induced by cotton pellets, meanwhile for its gastroprotective effects were evaluated two technics  of severe gastric ulcers using like ulcerogenic agent the absolute ethanol (1 mL/200 g) and the indomethacin (500 mg/kg). In the experimental design were used doses of 200, 400 and 800 mg/kg of weight. As positive controls were used: indomethacin 5 mg/kg (chronic inflamation model), atropine 20 mg/kg (model of ulcers by absolute ethanol) y ranitidine 100 mg/kg (model of ulcers by indomethacine) and like negative control was used filtered water. Results: The extract of Capraria biflora L., provided antinflamatory activity to all studied doses. The 200 mg/kg dose showed statistically significant similar results to indomethacin, while the 400 and 800 mg/kg were significant higher to this control. In addition, it was proofed the gastroprotective effect of the extract through the model of ulcer by absolute ethanol, to all studied doses with inhibition percents similar to atropine. Similar results were obtained with the model of ulcers by indomethacin being the 400 and 800 mg/kg doses the most active with percents of inhibition similar to ranitidine. Conclusions: The results warrant the gastroprotective and anti-inflammatory potential of the evaluated extract.

 

Citation Format: Valido-Díaz A, Vicet-Muro L, Boffill-Cárdenaz M, Pizarro-Espín A, Valdés-Álvarez M, Blanco Machado F (2015) Preclinical evaluation of antinflamatory and gastroprotective activity of the liquid extract from the leaves of Capraria biflora L. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S108. Abstract nr PPP-16.