PPP-17: PHYTOCHEMICAL SCREENING, GASTOPROTECTIVE ACTIVITY AND SEVERE TOXICITY OF Cnidoscolus chayamansa MC. VAUGH LEAVES

J Pharm Pharmacogn Res 3(suppl. 1): S109, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Poster

PPP-17: PHYTOCHEMICAL SCREENING, GASTOPROTECTIVE ACTIVITY AND SEVERE TOXICITY OF Cnidoscolus chayamansa MC. VAUGH LEAVES

Mena Y1, González DM2, Valido A1, Pizarro A1, Castillo O1, Blanco F1.

1Experimental Toxicology Unit. Villa Clara Medical College. Cuba. E-mail: deodelsybt@ucm.vcl.sld.cu
2Chemistry – Pharmacy Faculty. Central University “Marta Abreu” de Las Villas, Cuba.

 

Introduction: The specie Cnidoscolus chayamansa MC. Vaugh is an important nutritive source because of its high percent of proteins and minerals. Traditionally, it is used for diabetes, obesity, arthritis and anti-inflammatory in several disturbances associated to inflammatory processes. Objective:  Due to the interest of performing this investigation to evaluate the gastoprotective activity and its secure usage through oral way of the leaves of this specie. Methods: Also there were identified the principal groups of secondary metabolites present in liquid, ethanolic and ethereal extracts of the dried leaves through a phytochemical screening. It was carried out a study of severe oral toxicity through the procedure of fixes dose (5000 mg/kg) and the gastroprotection though an experimental model of gastric severe ulcers induced by absolute ethanol (1000, 2000 and 4000 mg/kg). In both studies were used rats of the line Sprague Dawley. Results: The corporal mass as indicator of the toxicity was according to the growing curve of and the line of the biological model used. There were found differences in the composition of the secondary metabolites for the three extracts. In the gastroprotective study we could observed a progressive rising of inhibition percent of the ulceration grade from 21% to the dose of 1000 mg/kg to 99 and 100% to the dose of 2000 mg/kg and 4000 mg/kg respectively. The values obtained in this case did not show significant statistic differences in relation to omeprazole used like positive control. Conclusions: The results warrant the gastroprotective potential of the evaluated extract and its security trough the oral way.

 

Citation Format: Mena Y, González DM, Valido A, Pizarro A, Castillo O, Blanco F (2015) Phytochemical screening, gastoprotective activity and severe toxicity of Cnidoscolus chayamansa MC. Vaugh leaves. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S109. Abstract nr PPP-17.