PPP-18: ASSEMENT OF Agave brittoniana NATURAL PRODUCTS ON EXPERIMENTAL METABOLIC SYNDROME

J Pharm Pharmacogn Res 3(suppl. 1): S110, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Poster

PPP-18: ASSEMENT OF Agave brittoniana NATURAL PRODUCTS ON EXPERIMENTAL METABOLIC SYNDROME

González-Madariaga Y1, Orestes-Guerra J2, Nieto-Reyes L2, Castillo-Alfonso O1, Santiesteban-Muñoz D1, Toledo-Soriano R1, Casanova-Noche P3.

1Experimental Toxicology Unit. Villa Clara Medical College, Cuba. E-mail: yiselmadariaga@infomed.sld.cu
2Chemistry – Pharmacy Faculty. Central University “Marta Abreu” de Las Villas, Cuba.
3Medicine Faculty, Villa Clara Medical College, Cuba.

 

Introduction: Finding new pharmacological objectives allowing the metabolic syndrome control in medicinal plants constitutes one of the main investigation lines developed worldwide by numerous researchers. Objective: Assessment of the pharmacological activity of different natural products derived from Agave brittoniana Trel. in an experimental model of metabolic syndrome. Methods: A rich furostanic-espirostanic saponin n-butanolic extract from the leaves of A. brittoniana was obtained. Next, this saponin crude was fractionated by column chromatography, using methanol mixtures. The n-butanolic extract and two fractions obtained from it were used for biological researches. The experimental metabolic syndrome was achieved supplying a sucrose solution to 35% to male Wistar rats recently weaned during 18 weeks. The natural products were orally administered (1 mg/kg) during 14 days after the metabolic syndrome induction and the hyperglucidic diet was maintained so far. Biometrics and lipidic parameters, and the arterial tension were registered. Results: The A. brittoniana products diminished significantly the body weight when concluding the study. The best results were obtained in the more polar saponin fraction. The triglyceride, systolic and diastolic arterial tension values showed substantial reductions in all the A. brittoniana products tested. Conclusions: The n-butanolic extract of A. brittoniana and two fractions obtained from it revealed effectiveness in the reduction of body weight, triglycerides and arterial tension in a model of metabolic syndrome.

 

Citation Format: González-Madariaga Y, Orestes-Guerra J, Nieto-Reyes L, Castillo-Alfonso O, Santiesteban-Muñoz D, Toledo-Soriano R, Casanova-Noche P (2015) Assement of Agave brittoniana natural products on experimental metabolic syndrome. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S110. Abstract nr PPP-18.