PPP-23: SPONTANEOUS WITHDRAWAL IN SPRAGUE DAWLEY RATS EXPOSED TO THE COMBUSTION PRODUCTS OF Mimosa pudica

J Pharm Pharmacogn Res 3(suppl. 1): S115, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Poster

PPP-23: SPONTANEOUS WITHDRAWAL IN SPRAGUE DAWLEY RATS EXPOSED TO THE COMBUSTION PRODUCTS OF Mimosa pudica

Fong O1, Berenguer CA1, de la Vega JE1, Mira H1, Salas H1, Álvarez F2.

1Centro de Toxicología y Biomedicina (TOXIMED), Autopista Nacional Km 1 ½. Santiago de Cuba. Cuba. Teléfono: + (53)(22) 64-3796. E-mail: onel.fong@medired.scu.sld.cu
2Departamento de Biología, Facultad de Ciencias Naturales, Universidad de Oriente, Santiago de Cuba, Cuba.

 

Introduction: Toxic plants are those, which produce injuries, disease or cause death to humans or animals. There are about 388 species of plants considered toxic in Cuba, including native or exotic. However, there are plants being used as drug enhancers like marihuana, in the southeastern provinces of Cuba, such as Mimosa pudica, and are not included in such inventories. This research aims to evaluate the addictive potential of the combustion products of Mimosa pudica plant in Sprague Dawley rats. Material and Methods: We developed a plant phytochemical screening and it was evaluated the addictive potential through a non-precipitated withdrawal test, using a plant doses of 1000 mg/kg and a reference group with chlordiazepoxide 64 mg/kg. Results: The phytochemical screening showed the presence of triterpenes, steroids, saponins, carbohydrates, alkaloids and phenolic compounds. The plant showed signs of physical dependence, characterized by the manifestation of signs hyperactivity (excitability and aggressiveness), piloerection and soft feces, as well as decreased body weight and increased rectal temperature during the withdrawal period. Conclusions: The plant showed signs of mild dependence similar to chlordiazepoxide.

 

Citation Format: Fong O, Berenguer CA, de la Vega JE, Mira H, Salas H, Álvarez F (2015) Spontaneous withdrawal in Sprague Dawley rats exposed to the combustion products of Mimosa pudica. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S115. Abstract nr PPP-23.