PPP-24: PRECLINICAL VALIDATION OF THE Costus pictus D.DON (CAÑA MEXICANA) SPECIES

J Pharm Pharmacogn Res 3(suppl. 1): S116, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Poster

PPP-24: PRECLINICAL VALIDATION OF THE Costus pictus D.DON (CAÑA MEXICANA) SPECIES

Blanco Y, Victoria MC, Martínez I, López M, Acosta L, Brito G, Duménigo A, Morejón Z, Morón F, Cabrera H, Martínez JM.

Laboratorio Central de Farmacología. Facultad de Ciencias Médicas ¨Salvador Allende¨. Carvajal # 56 % calle A y Diana, Cerro, Habana. Código postal 12000. E-mail: yiselblanco@infomed.sld.cu

 

Introduction: Costus pictus belong to Zingiberaceae family, in Cuba is known as caña mexicana and decoction of leaves and fresh stems is traditionally used for urinary disorders like infections, lithiasis and renal colic. The aim of this work was to identify the main groups of secondary metabolites and to validate pharmacology and toxicology properties of a decoction of fresh leaves and stems from C. pictus. Methods: Airs fresh parts were collected and conducted a farmacognostic and pharmacology study. A phytochemical screening identified the main groups of secondary metabolites present in the decoction 30%. Analgesic activity was determinate by contortions induced by acid acetic (0.75% via i.p) and removal of the tail submerged into water at 55°C. Anti-inflammatory activity was assay in cotton-induced granulomas in rats and relaxations of smooth musculature in urethra. Toxicology test were CTA and toxicity in repeat doses. Results: Main secondary metabolites were phenol, tannins, and flavonoids. Decoction of C. pictus inhibits contractions of the urethra induced by KCl. The toxicology study not presents nor intoxications, nor death. It significantly reduced the painful response both models, but there was no anti-inflammatory effect on cotton-induced granuloma. Conclusions: The results contributed to validate the traditional use of C. pictus fresh leaves and stems in order to relieve the pain caused by renal diseases.

 

Citation Format: Blanco Y, Victoria MC, Martínez I, López M, Acosta L, Brito G, Duménigo A, Morejón Z, Morón F, Cabrera H, Martínez JM (2015) Preclinical validation of the Costus pictus D.Don (caña mexicana) species. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S116. Abstract nr PPP-24.