PTS-42: TOXICOLOGICAL STUDIES TO THE PRODUCTS CODASAL PLUS, CODAHUMUS 20, CODACÍTRICOS, CODAMIN RADICULAR, CODAMIN B-Mo AND CODAN

J Pharm Pharmacogn Res 3(suppl. 1): S134, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Poster

PTS-42: TOXICOLOGICAL STUDIES TO THE PRODUCTS CODASAL PLUS, CODAHUMUS 20, CODACÍTRICOS, CODAMIN RADICULAR, CODAMIN B-Mo AND CODAN USED IN THE AGRICULTURE AS BIO-FERTILIZERS

García G, Casanova M, Jorge N, Pardo GL.

Center of Study for the Investigations and Biological Evaluations (CEIEB), Institute of Pharmacy and Foods, University of Havana, Cuba. E-mail ggarcia@ifal.uh.cu

 

Introduction: The products CODA from Sustainable Agrosolutions SA (CodasalPlus, Codahumus 20, Codacítricos, Codamin Radicular, Codamin B-Mo, and Codan) are composed by a natural mixture of amino acids, and biostimulant sand are used to get maximum yields and qualities of crop growing by improving earth and water. In this study we carried out the first barrier toxicity assays for these products: Material and Methods: It were used the norms described in the Technical Guidelines of the Organization for the Cooperation and Development (OECD), and other reported by the International Organization of Standardization (ISO) for tests of Sensitization, Oral and Dermal Acute Toxicity, and Ocular and Dermal Irritability. Results: The results indicated that the above mentioned products are not sensitizing agents. In the case of Ocular Irritation test, only the Codacítricos was rejected do to its toxicity to ocular structures. In relation to the Dermal Irritation, the index or punctuation was 0, indicating the dermal safeness of the bio-fertilizers. Concerning the Oral Acute Toxicity test, all the products analyzed passed the test. Finally, regarding the Dermal Acute Toxicity test, visible damages were localized in the skin, but non deaths except in the Codahumus 20 were observed. In this case, it was necessary to reduce the dose. Conclusions: These products can be used and manipulated by humans, providing the suitable cautions emanated from this study.

 

Citation Format: García G, Casanova M, Jorge N, Pardo GL (2015) Toxicological studies to the products Codasal Plus, Codahumus 20, Codacítricos, Codamin Radicular, Codamin B-MO and Codan used in the agriculture as bio-fertilizers. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S134. Abstract nr PTS-42.