PTS-47: TOXICITY STUDIES OF Curcuma longa EXTRACTS

J Pharm Pharmacogn Res 3(suppl. 1): S139, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Poster

PTS-47: TOXICITY STUDIES OF Curcuma longa EXTRACTS

Quintana N, García JJ.

Laboratorio de Fito y Apifármacos, Empresa Provincial de Farmacias y Ópticas Pinar del Río. Pedro Téllez #72, Pinar del Río. E-mail: labsalplan@princesa.pri.sld.cu

 

Introduction: The Cumin extract is a pharmaceutical form prepared from the Curcuma longa L.  The C. longa is harvested from the Northeast of Pinar del Rio province, Cuba. From 1995 was isolated an antirretroviral protein (tyrphostine) of 18-19D molecular weight (Garcia Martin, 2003). The toxicity in C. longa extracts was our principal objective in this case. Material and Methods: Biological assays were realized using 40 female mice from Switzerland Stock of-1 (Barcelona), with maintenance diet using an aqueous extract of C. longa. Twenty mice received extract and twenty were the control group. This group received a standard diet. Experimental studies with 4 mg/kg mouse per day= 0.4 mg/kg mouse per day with curcumin in human doses. The evaluation made to the mice was about in the Thomas media measure, weight sequence, muscular coordination method, String-Test of Miguel Blasco (Don’t fall in a row), Spontaneous explorer (Labyrinth test in T: explore the first arm of the labyrinth in 60 seconds). Passing four weeks the mice were sacrificed and we take blood from the neck, a piece of liver (Lipid peroxidation) looking for malonialdehyde concentration by thiobarbituryc method and proteins concentrated by Lowry method. Results and Conclusions: Curcuma longa extracts did not cause any toxicity in mice, besides decreased lipids peroxides in blood and finally the 25 higher doses of Curcuma are not toxics.

 

Citation Format: Quintana N, García JJ (2015) Toxicity studies of Curcuma longa extracts. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S139. Abstract nr PTS-47.