J. Pharm. Pharmacogn. Res., vol. 12, no. 6, pp. 1170-1177, Nov-Dec 2024.

DOI: https://doi.org/10.56499/jppres24.1969_12.6.1170

Original Article

Anti-fatigue activity of syrup containing ethanolic extract of kencur (Kaempferia galanga L.) rhizome in Wistar rats

[Actividad antifatiga del jarabe que contiene extracto etanólico de rizoma de kencur (Kaempferia galanga L.) en ratas Wistar]

Devinta Julian Tupenalay, Sukardiman^*, Suciati, Rice Disi Oktarina, Rosita Handayani

Pharmaceutical Science Department, Faculty of Pharmacy, Airlangga University, 60115, Surabaya, Indonesia.

*E-mail: sukardiman@ff.unair.ac.id

Abstract

Context: The Javanese culture includes the consumption of traditional herbal medicine known as jamu. One commonly consumed type of jamu to enhance physical fitness and alleviate fatigue is Beras Kencur, which contains the kencur (Kaempferia galanga) rhizome. Although it has been used for generations, scientific testing on the effects of K. galanga as an anti-fatigue agent remains rare.

Aims: To assess the anti-fatigue effects of K. galanga rhizome extract (KGE) through an endurance swimming test conducted on male Wistar rats.

Methods: This study involved 30 Wistar rats randomly allocated into 5 groups: a negative control group administered with syrup vehicle, a positive control group receiving 9 mg/kg body weight (BW) of caffeine syrup, and three treatment groups receiving KGE syrup at different doses - dose 1 (37 mg/kg BW), dose 2 (73.5 mg/kg BW), and dose 3 (147 mg/kg BW). The anti-fatigue effect was evaluated based on the duration of struggling in the water in the endurance swimming test.

Results: The results demonstrated that the treatment groups exhibited a significant anti-fatigue effect compared to the negative control group. The administration of a syrup formulation containing KGE at doses 1 (37 mg/kg BW), 2 (73.5 mg/kg BW), and 3 (147 mg/kg BW) revealed an anti-fatigue effect on male Wistar rats.

Conclusions: The administration of K. galanga demonstrated dose-dependent anti-fatigue activity in rats. The most effective dose was found to be 147 mg/kg body weight in rats.

Keywords: fatigue; jamu; kencur, Kaempferia galanga; swimming test.

Resumen

Contexto: La cultura javanesa incluye el consumo de la medicina herbaria tradicional conocida como jamu. Un tipo de jamu que se consume habitualmente para mejorar la condición física y aliviar la fatiga es el Beras Kencur, que contiene el rizoma de kencur (Kaempferia galanga). Aunque se ha utilizado durante generaciones, las pruebas científicas sobre los efectos de K. galanga como agente antifatiga siguen siendo escasas.

Objetivos: Evaluar los efectos antifatiga del extracto de rizoma de K. galanga (KGE) mediante una prueba de resistencia de nado realizada en ratas Wistar macho.

Métodos: En este estudio participaron 30 ratas Wistar asignadas aleatoriamente en 5 grupos: un grupo de control negativo al que se le administró jarabe de vehículo, un grupo de control positivo que recibió 9 mg/kg de peso corporal (PC) de jarabe de cafeína y tres grupos de tratamiento que recibieron jarabe de KGE a diferentes niveles. dosis: dosis 1 (37 mg/kg de peso corporal), dosis 2 (73,5 mg/kg de peso corporal) y dosis 3 (147 mg/kg de peso corporal). El efecto antifatiga se evaluó basándose en la duración del esfuerzo en el agua en la prueba de natación de resistencia.

Resultados: Los resultados demostraron que los grupos de tratamiento exhibieron un efecto antifatiga significativo en comparación con el grupo de control negativo. La administración de una formulación de jarabe que contiene KGE en las dosis 1 (37 mg/kg de peso corporal), 2 (73,5 mg/kg de peso corporal) y 3 (147 mg/kg de peso corporal) reveló un efecto antifatiga en ratas Wistar macho.

Conclusiones La administración de K. galanga demostró actividad antifatiga dosis-dependiente en ratas. La dosis más eficaz fue 147 mg/kg de peso corporal en ratas.

Palabras Clave: fatiga; jamu; Kaempferia galanga; kencur; prueba de natación.

 

https://jppres.com/jppres/pdf/vol12/jppres24.1969_12.6.1170.pdf

Citation Format: Tupenalay DJ, Sukardiman, Suciati, Oktarina RD, Handayani R (2024) Anti-fatigue activity of syrup containing ethanolic extract of kencur (Kaempferia galanga L.) rhizome in Wistar rats. J Pharm Pharmacogn Res 12(6): 1170–1177. https://doi.org/10.56499/jppres24.1969_12.6.1170

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