Anti-hyperuricemic and neuroprotective effects of Populus nigra

Excerpt:


J Pharm Pharmacogn Res 6(6): 471-482, 2018. Original Article | Artículo Original Anti-hyperuricemic and neuroprotective effects of Populus nigra L. (Saliacaceae) flower buds used in Algerian folk medicine [Efectos antihiperturicémicos y neuroprotectores de los brotes de Populus nigra L. (Saliacaceae) utilizados en la medicina popular argelina] Nadjet Debbache-Benaida1*, Meriem Berboucha1, Karima Ayouni1, Dina Atmani1, Cheraft Nassima1, Hania Boudaoud1, … Continue reading Anti-hyperuricemic and neuroprotective effects of Populus nigra

J Pharm Pharmacogn Res 6(6): 471-482, 2018.

Original Article | Artículo Original

Anti-hyperuricemic and neuroprotective effects of Populus nigra L. (Saliacaceae) flower buds used in Algerian folk medicine

[Efectos antihiperturicémicos y neuroprotectores de los brotes de Populus nigra L. (Saliacaceae) utilizados en la medicina popular argelina]

Nadjet Debbache-Benaida1*, Meriem Berboucha1, Karima Ayouni1, Dina Atmani1, Cheraft Nassima1, Hania Boudaoud1, Noureddine Djebli2, Djebbar Atmani1

1Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia 06000, Algeria
2Laboratory of Microbiology and Plant Biology, Faculty of Sciences, University of Mostaganem, Mostaganem 27000, Algeria.

*E-mail: nadjet.benaida@univ-bejaia.dz; benaida.nadjet@yahoo.com

Abstract

Context: Populus nigra L., is a species of cottonwood poplar that belongs to the Salicaceae family, is cultivated in multiple areas in Algeria, with an Algerian name of Safsaf.

Aims: To evaluate the Populus nigra flower buds extract for its effects on brain modifications against aluminum-induced neurotoxicity in mice. The hypouricemic action of the extract was also evaluated.

Methods: To evaluate the effect of extract on AlCl3-induced neurotoxicity on mice a battery of tests was performed to assess a spectrum of learning and memory functions. The hypouricemic action of the extract was studied by the measure of uric acid levels and liver xanthine oxidoreductase activity in normal and hyperuricemic mice.

Results: Co-administration of P. nigra extract (200 mg/kg) and AlCl3 (100 mg/kg/day) combined with D-galactose (200 mg/kg/day) during four weeks was found to antagonize the harmful effects of AlCl3 by restoring all the test parameters. Moreover, extract restored the pyramidal cells to near normal in cerebral cortex of mice. Extract, when administered three times orally to the normal and oxonate-induced hyperuricemic mice, was able to elicit significantly hypouricemic effect comparable to that of allopurinol.

Conclusions: P. nigra flower buds extract can be considered as food enabling to antagonize AlCl3 toxicity and to control serum uric acid levels.

Keywords: aluminum toxicity; Alzheimer diseases; hyperuricemia; Populus nigra; xanthine oxidoreductase.

Resumen

Contexto: Populus nigra L. es una especie de álamo que pertenece a la familia Salicaceae, se cultiva en múltiples áreas en Argelia, con un nombre argelino de Safsaf.

Objetivos: Evaluar el extracto de yemas florales de Populus nigra, por sus efectos sobre las modificaciones cerebrales frente a la neurotoxicidad inducida por aluminio en ratones. La acción hipouricemic del extracto también fue evaluada.

Métodos: Para determinar el efecto del extracto sobre la neurotoxicidad inducida por AlCl3 en ratones, se realizó una batería de pruebas para evaluar un espectro de funciones de aprendizaje y memoria. La acción hipouricemia del extracto se estudió mediante la medición de los niveles de ácido úrico y la actividad xantina oxidorreductasa del hígado en ratones normales e hiperuricémicos.

Resultados: La administración conjunta del extracto de P. nigra (200 mg/kg) y AlCl3 (100 mg/kg/día), combinado con D-galactosa (200 mg/kg día), durante cuatro semanas, antagonizó los efectos nocivos de AlCl3 al restaurar todos los parámetros de prueba. Además, el extracto restauró las células piramidales a casi normal en la corteza cerebral de ratones. El extracto, cuando se administró tres veces por vía oral a los ratones hiperuricémicos normales e inducidos por oxatos, fue capaz de provocar un efecto significativamente hipouricémico, comparable al del alopurinol.

Conclusiones: El extracto de los brotes de flor de P. nigra puede considerarse como un alimento que permite antagonizar la toxicidad de AlCl3 y controlar los niveles séricos de ácido úrico.

Palabras Clave: enfermedad de Alzheimer; hiperuricemia; Populus nigra; toxicidad del aluminio; xantina oxidorreductasa.

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Citation Format: Debbache-Benaida N, Berboucha M, Ayouni K, Atmani D, Cheraft N, Boudaoud H, Djebli N, Atmani D (2018) Anti-hyperuricemic and neuroprotective effects of Populus nigra L. (Saliacaceae) flower buds used in Algerian folk medicine. J Pharm Pharmacogn Res 6(6): 471–482.

© 2018 Journal of Pharmacy & Pharmacognosy Research (JPPRes)

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