Antihypertrophic effect of Desmodium gangeticum root extract

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J Pharm Pharmacogn Res 2(5): 129-137, 2014. DOI: https://doi.org/10.56499/jppres14.032_2.5.129 Original Article Desmodium gangeticum root extract attenuates isoproterenol-induced cardiac hypertrophic growth in rats. [El extracto de raíz de Desmodium gangeticum atenúa el crecimiento hipertrófico cardíaco inducido por isoproterenol en ratas] Divya Hitlera, Parthasarathy Arumugama, Mathivanan Narayanasamyb, Elangovan Vellaichamya٭ aDepartment of Biochemistry; bCentre for Advanced Studies in Botany, University of Madras, … Continue reading Antihypertrophic effect of Desmodium gangeticum root extract

J Pharm Pharmacogn Res 2(5): 129-137, 2014.

DOI: https://doi.org/10.56499/jppres14.032_2.5.129

Original Article

Desmodium gangeticum root extract attenuates isoproterenol-induced cardiac hypertrophic growth in rats.

[El extracto de raíz de Desmodium gangeticum atenúa el crecimiento hipertrófico cardíaco inducido por isoproterenol en ratas]

Divya Hitlera, Parthasarathy Arumugama, Mathivanan Narayanasamyb, Elangovan Vellaichamya٭

aDepartment of Biochemistry; bCentre for Advanced Studies in Botany, University of Madras, Guindy campus, Chennai-600 025 Tamil Nadu, India.
*E-mail:vellaie@gmail.com
Abstract

Context: Desmodium gangeticum (L) DC (Fabaceae; DG), a medicinal plant that grows in tropical habitats, is widely used to treat various ailments including digestive and inflammatory disorders.
Aims: To investigate the possible cardioprotective activity of a DG root extract against isoproterenol (ISO)-induced left ventricular cardiac hypertrophy (LVH) in adult Wistar rats.
Methods: Daily intraperitoneal administration of ISO (10 mg/kg body weight, single injection) for 7 days induced LVH in rats. The LVH rats were post-treated orally with DG (100 mg/kg body weight) for a period of 30 days. Thereafter, changes in heart weight (HW) and body weight (BW), HW/BW ratio, percent of hypertrophy, collagen accumulation, activities of matrix metalloproteinase (MMP) -2 and -9, superoxide dismutase (SOD) and catalase (CAT) enzymes, and the level of an oxidative stress marker, lipid peroxide (LPO), were determined.
Results: HW/BW ratio, an indicator of hypertrophic growth, was significantly reduced in DG root post-treated LVH rats as compared with that for the non-treated LVH rats. The altered levels of ventricular LPO, collagen, MMPs-2 and -9, and antioxidant enzymes in the ISO-treated animals reverted back to near normal upon DG treatment. Further, the anti-hypertrophic activity of DG was comparable to that of the standard drug losartan (10 mg/kg).
Conclusions: The results of the present study suggest that the aqueous root extract of DG exhibited anti-hypertrophic activity in-vivo by inhibiting ISO-induced ROS generation and MMP activities.

Keywords: Desmodium gangeticum; cardiac hypertrophy; collagen; isoproterenol; losartan; MMPs.

Resumen

Desmodium gangeticum (L) DC (Fabaceae; DG), una planta medicinal que crece en hábitats tropicales, se usa ampliamente para tratar varias dolencias, incluyendo desórdenes digestivos e inflamatorios.
Objetivos: Investigar la posible actividad cardioprotectora del extracto de raíz de DG contra la hipertrofia cardiaca ventricular izquierda (LVH) inducida por isoproterenol (ISO) en ratas Wistar adultas.
Métodos: La administración intraperitoneal diaria de ISO (10 mg/kg peso corporal, en una sola inyección) por 7 días indujo LVH en ratas. La LVH fue tratada oralmente con DG (100 mg/kg peso corporal) por un periodo de 30 días. Posteriormente, se determinaron cambios en el peso del corazón (HW) y peso corporal (BW), la relación de HW/BW, porcentaje de la hipertrofia, la acumulación de colágeno, las actividades de metaloproteinasas de matriz (MMP)-2 y -9, las enzimas superóxido dismutasa (SOD) y catalasa (CAT), y el nivel de un marcador de estrés oxidativo, lipoperóxido (LPO).
Resultados: La relación HW/BW, un indicador de crecimiento hipertrófico, se redujo significativamente en ratas tratadas con extractos de la raíz de DG después de la inducción de LVH en comparación con las ratas con LVH no tratadas. Las concentraciones alteradas de LPO ventricular, colágeno, MMP-2 y -9, y las enzimas antioxidantes en los animales tratados con ISO volvieron a valores cercanos a los normales después del tratamiento con DG. Además, la actividad anti-hipertrófica de DG fue comparable a la del fármaco de referencia losartán (10 mg/kg).
Conclusiones: Los resultados del presente estudio sugieren que el extracto acuoso de la raíz de DG presenta actividad anti-hipertrófica in-vivo mediante la inhibición de la generación de ROS inducida por ISO y las actividades de MMP.

Palabras Clave: Colágeno; Desmodium gangeticum; hipertrofia cardiaca; isoproterenol; losartán; MMPs.

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Citation Format: Hitler D, Arumugam P, Narayanasamy M, Vellaichamy E (2014) Desmodium gangeticum root extract attenuates isoproterenol-induced cardiac hypertrophic growth in rats. J Pharm Pharmacogn Res 2(5): 129-137. DOI: https://doi.org/10.56499/jppres14.032_2.5.129
This article has been cited by:
Fathima S, Murthy SV (2018) Current pharmacological status of cardioprotective plants against isoproterenol induced myocardial infarction. Asian Journal of Pharmaceutical and Clinical Research, 11(4): 17-27. DOI: 10.22159/ajpcr.2018.v11i4.24158

© 2014 Journal of Pharmacy & Pharmacognosy Research (JPPRes)

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