Antiulcer effect of Helminthostacys zeylanica

J. Pharm. Pharmacogn. Res., vol. 10, no. 3, pp. 508-516, May-June 2022.

Original Article

Antiulcer effect of Helminthostachys zeylanica (L.) Hook. root extract on ethanol-induced acute gastric lesion in Wistar rats

[Efecto antiulceroso del extracto de raíz de Helminthostachys zeylanica (L.) Hook. sobre la lesión gástrica aguda inducida con etanol en ratas Wistar]

Fitrya*, Annisa Amriani, Rennie Puspa Novita, Friscilla Nindita Pamela

Department of Pharmacy, Universitas Sriwijaya, South Sumatera, Indonesia.



Context: Helminthostachys zeylanica is well known as a traditional medicine with various pharmacological activities, including antioxidant and anti-inflammatory. These activities are needed in the treatment of gastric ulcers.

Aims: To evaluate the effectiveness of H. zeylanica as an antiulcer agent on acute peptic ulcer.

Methods: The antiulcer effect of the H. zeylanica ethanolic extract (100, 200 and 400 mg/kg BW) was studied through ulcer index, physicochemical properties of gastric juice and histopathological analysis in male Wistar rats.

Results: The extract reduces ulcer index, gastric fluid volume, total acidity and increases gastric protection factors such as pH and mucus levels. These results were not significantly different from omeprazole (p>0.05). Photomicrograph analysis showed improvement of membrane structure in extract-treated animals.

Conclusions: H. zeylanica extract could be valued as an antiulcer agent.

Keywords: Helminthostachys zeylanica; gastric ulcer; ulcer index.

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Contexto: Helminthostachys zeylanica es bien conocida como medicina tradicional con diversas actividades farmacológicas, incluyendo antioxidante y antiinflamatoria. Estas actividades son necesarias en el tratamiento de las úlceras gástricas.

Objetivos: Evaluar la eficacia de H. zeylanica como agente antiulceroso en úlcera péptica aguda.

Métodos: Se estudió el efecto antiulceroso del extracto etanólico de H. zeylanica (100, 200 y 400 mg/kg de peso corporal) a través del índice de úlcera, propiedades fisicoquímicas del jugo gástrico y análisis histopatológico en ratas Wistar macho.

Resultados: El extracto reduce el índice de úlceras, el volumen de líquido gástrico, la acidez total y aumentar los factores de protección gástrica como el pH y los niveles de moco. Estos resultados no fueron significativamente diferentes del omeprazol (p>0,05). El análisis de fotomicrografía mostró una mejora de la estructura de la membrana en los animales tratados con el extracto.

Conclusiones: El extracto de H. zeylanica podría ser valorado como un agente antiulceroso.

Palabras Clave: Helminthostachys zeylanica; índice de úlcera; úlcera gástrica.

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Citation Format: Fitrya, Annisa A, Rennie PN, Friscilla NP (2022) Antiulcer effect of Helminthostachys zeylanica (L.) Hook. root extract on ethanol-induced acute gastric lesion in Wistar rats. J Pharm Pharmacogn Res 10(3): 508–516.

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