J Pharm Pharmacogn Res 2(Suppl. 1): S47, 2014
Special supplement with the abstract book of LATINFARMA 2013
C 019: OZONE´S THERAPEUTICAL TARGETS. BASIS OF THEIR PLEIOTROPIC EFFECTS
León Fernández OS, Díaz Soto MT, Dranguet Vaillant J.Pharmacy and Food Institute of the University of Havana, Cuba.
Ozone´s therapeutic effects have been demonstrated in different diseases which are “seeminlgy” no connected between them. Ozone Oxidative Pre/Postconditioning mechanism showed that ozone administration in low doses and controlled number of treatments was able to increase antioxidant endogenous defence systems therefore a condition in order to expect a therapeutical success with ozonetherapy is that disease has a chronic oxidative stress as component of its etiology so cellular redox balance happen in a therapeutical target of medical ozone. Superoxide dismutase activity is an enzyme which is involved in different diseases, mainly vascular disorders. At the same time, adenosine plays an important role in stress conditions. Both, superoxide dismutase and adenosine, are ubiquitous molecules, achieve its effects through signal transductions and they are modified in specific way by ozonetherapy. Above mentioned ozone´s therapeutical targets are shown through diseases as ischemic syndrome, diabetes and disc hernia which demonstrate ozonetherapy pleiotropic effects.