Category Archives: Chronopharmacology

C 048: THE ROLE OF ACTIGRAPHY IN THE STUDY OF THE SLEEP-WAKE CYCLE

Chronopharmacology
J Pharm Pharmacogn Res 2(Suppl. 1): S141, 2014

Special supplement with the abstract book of LATINFARMA 2013

Conference

C 048: THE ROLE OF ACTIGRAPHY IN THE STUDY OF THE SLEEP-WAKE CYCLE

Meira e Cruz M.

Portuguese Association of Chronobiology and Sleep Medicine. Cardiovascular Autonomic Function Lab, Lisbon Faculty of Medicine, Portugal. E-mail: mmc@gentesaudavel.pt
Abstract

In the recent years activity-based sleep wake monitoring acquired an important role as a measuring tool in sleep research and sleep medicine. Although not as accurate as PSG for evaluating some sleep parameters, actigraphy has the ability to record continuously for long time periods and most often seems more reliable than sleep logs preventing the need of long time observations which are most of the times unfeasible from a practical point of view. Adults and children sleep patterns can be analyzed with the use of this technique which provides important validated objective information either related with sleep and wake schedules, daytime and nighttime activity as well as environment light. Actigraphic analysis may also have a role in the medical care of patients with different sleep disturbances, namely circadian rhythm disorders, insomnia, restless legs syndrome and periodic limb movements. More rarely actigraphy may be useful for selected patients with suspected sleep related breathing disorders. Despite the different conditions for which actigraphy may be helpful, some methodological issues need to be respected in order to obtain clinically useful and reproducible data. In this lecture, author will provide an overview about actigraphy as a tool with great value on sleep lab both for research and for clinical purposes.

C 047: CHRONOPHARMACOLOGY

Chronopharmacology
J Pharm Pharmacogn Res 2(Suppl. 1): S141, 2014

Special supplement with the abstract book of LATINFARMA 2013

Conference

C 047: CHRONOPHARMACOLOGY

 Valdés Y.

Faculty of Pharmacy and Foods. 2317, 222nd St. La Coronela. La Lisa. Havana. Cuba.
Abstract

Biological rhythms influence many body functions like metabolism, sleep pattern, hormone production and physiology. Variations in these functions cause changes both in disease state and in plasma drug concentrations. Diseases, such as hypertension, asthma, peptic ulcer, arthritis, myocardial infarction, congestive heart failure, stroke, cancer, follow the body’s circadian rhythm. Many systems in the human body such as hepatic and renal systems show variation in their function throughout a typical day. They are predictable systems, which require different amounts of drug at predictably different times within the circadian cycle in order to maximize desired and minimize undesired drug effect. Chronopharmacology considers that the drug therapy can be optimized by tailoring the dosing schedule based on chronobiological pattern. This has led to a new approach to the development of drug delivery systems. A number of chronotherapeutic medications, aiming at synchronizing medications and the intrinsic rhythms of disease have been developed in recent years. In this lecture, the concepts of biological rhythms, chronobiology, chronopharmacology and chronotherapy for various diseases will be discussed.