Category Archives: Drug Design and Action


J Pharm Pharmacogn Res 2(Suppl. 1): S19, 2014

Special supplement with the abstract book of LATINFARMA 2013



Pérez J.

Ministerio de Salud Pública, La Habana, Cuba.

This paper is an analysis of the current situation of the Global Pharmaceutical Industry. The analysis includes the global pharmaceutical market and its growing in the last ten years, the distribution of these markets around the world. The paper identifies the top ten pharmaceutical industries and the top ten drugs selling last year. The analysis embraces the megamerger industries and the specialization of the manufacturers. Development and research drugs, the control of the knowledge and scientific information, the functioning of the national and the international regulatory authorities, international trade and intellectual property rights and the challenge of the future in this area are other subjects for discussing.

Nanocarriers for skin delivery of cosmetic antioxidants

J Pharm Pharmacogn Res 2(4): 73-92, 2014.

Review | Revisión

Nanocarriers for skin delivery of cosmetic antioxidants.

[Nanovehículos para la liberación en piel de cosméticos antioxidantes]

Lucia Montenegro

Department of Drug Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy.

The demand of natural skin care products is steadily growing since consumers perceive them as safe. Currently, cosmetic manufacturers are focusing their efforts on developing innovative natural products to address skin-aging signs, thus meeting consumers’ needs of healthy appearance and well-being. To prevent or treat skin aging, topical supplementation with antioxidant is regarded as one of the most promising strategies. However, most antioxidants presently used in skin care formulations show unfavorable physicochemical properties such as excessive lipophilicity or hydrophilicity, chemical instability and poor skin penetration that actively limit their effectiveness after topical application. Therefore, nanocarriers such as liposomes, niosomes, microemulsions and nanoparticles have been widely investigated as delivery systems for antioxidants to improve their beneficial effects in the treatment of skin aging. In this article, the antioxidants most commonly used in anti-aging cosmetic products will be reviewed along with the nanocarriers designed to improve their safety and effectiveness.

Keywords: Anti-aging; antioxidant; cosmetic; nanocarrier; topical delivery system.


La demanda de los productos naturales para el cuidado de piel es cada vez mayor ya que los consumidores los perciben como seguros. En la actualidad, los fabricantes de cosméticos centran sus esfuerzos en el desarrollo de productos naturales innovadores para abordar los signos de envejecimiento de la piel y, por tanto, satisfacer las necesidades de apariencia saludable y el bienestar de los consumidores. La suplementación con antioxidantes tópicos está considerada como una de las estrategias más prometedoras para prevenir o tratar el envejecimiento de la piel. Sin embargo, la mayoría de los antioxidantes que se utilizan actualmente en las formulaciones de cuidado de la piel muestran propiedades fisicoquímicas desfavorables como lipofilia o hidrofilia excesivas, inestabilidad química y escasa penetración de la piel, que limita su eficacia después de la aplicación tópica. Por lo tanto, nanovehículos tales como liposomas, niosomas, microemulsiones y nanopartículas han sido ampliamente investigados como sistemas de liberación para antioxidantes, para mejorar sus efectos beneficiosos en el tratamiento de envejecimiento de la piel. En este artículo serán revisados los antioxidantes más utilizados en productos cosméticos en la lucha contra el envejecimiento, junto con los nanovehículos diseñados para mejorar la seguridad y la eficacia.

Palabras Clave: Antienvejecimiento; antioxidante; cosmético; nanovehículo; sistema de liberación tópica.

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Citation Format: Montenegro L (2014) Nanocarriers for skin delivery of cosmetic antioxidants. J Pharm Pharmacogn Res 2(4): 73-92.
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© 2014 Journal of Pharmacy & Pharmacognosy Research (JPPRes)