1Laboratório de Biopolímeros e Sensores – Instituto de Macromoléculas – Universidade Federal do Rio de Janeiro, Brasil. E-mail: email@example.com
2Programa de Engenharia Química – COPPE – Universidade Federal do Rio de Janeiro, Brasil.
The kinetics and spatial controls of drug delivery offers many advantages compared to conventional methods. These delivery systems often use biocompatible magnetic nanoparticles as maghemite to promote spatial control and synthetic biocompatible polymers as drug carriers to promote a kinetic control of this release. This study was focused study of the magnetic field influence on the release profile of cotrimoxazole inserted in PLGA-PEG-PLGA/maghemite nanocomposites prepared by melt mixing. The synthesized samples were prepared and characterized by 1H-NMR, FTIR, XRD, and magnetic force. The drug release profile was monitored by UV analysis along 6 hours with and without magnetic field. The release profile of the drug showed to be sustained and the presence of maghemite, in the presence of a magnetic field, were able to perform a magnetic constriction of the material, making the drug release faster than in the absence of the magnetic field. This release behavior may be useful to perform a fine tuning of the system, allowing the easier adjustment of the speed and amount of released drug, improving medical treatments and even the welfare of the patients.
Special supplement with the abstract book of LATINFARMA 2013
CO 052: CRITICAL POINTS TO CONSIDER WHEN DEVELOPING PHARMACEUTICAL PRODUCTS BASED ON MICROSPHERES CONTAINING PROTEINS
Macromolecular Chemistry Department, Center for Biomaterials (BIOMAT), University of Havana, Havana, Cuba. E-mail: firstname.lastname@example.org
Nowadays peptides and proteins are commonly used as the active principle of many pharmaceutical products. However the design of dosage forms with these biomolecules has some limitations related to the adverse events and the relatively short elimination half-life. Consequently novel protein administration systems have been investigated to exploit the therapeutic potential of them while simultaneously avoiding the limitations. Biodegradable microspheres are one of the most widely explored because they could (i) reduce the administration frequency of the product, (ii) maintain appropriate protein levels in the blood for an adequate period of time, (iii) decrease adverse events and hence (iv) improve the compliance of patients during the treatments. In the last decades numerous investigations about the encapsulation of therapeutic proteins have been developed but only a few products are already under clinical application. This is because the protein microencapsulation is a complex process governed by multiple factors that should be optimized in order to program the properties desired for a specific protein-loaded microsphere preparation. In addition, the properties of the encapsulated protein are often modified as a result of the encapsulation process, thus they should be carefully evaluated in order to demonstrate the ability of the protein to exert its biological function. On the other hand, microspheres are typically manufactured by an aseptic process because terminal sterilization (heat sterilization and gamma irradiation) results in premature degradation of the particles. Due to the complexity in the development and manufacturing process for microsphere drug products an appropriate quality control strategy should be designed. This talk reviews through practical examples, the current state of microspheres containing therapeutic proteins from basic research to its clinical application and debate controversial aspects related to the development of pharmaceutical products based on these novel drug delivery systems. Regulatory topics associated with these products are also discussed.
Nanocarriers for skin delivery of cosmetic antioxidants.
[Nanovehículos para la liberación en piel de cosméticos antioxidantes]
Department of Drug Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy. *E-mail: email@example.com
The demand of natural skin care products is steadily growing since consumers perceive them as safe. Currently, cosmetic manufacturers are focusing their efforts on developing innovative natural products to address skin-aging signs, thus meeting consumers’ needs of healthy appearance and well-being. To prevent or treat skin aging, topical supplementation with antioxidant is regarded as one of the most promising strategies. However, most antioxidants presently used in skin care formulations show unfavorable physicochemical properties such as excessive lipophilicity or hydrophilicity, chemical instability and poor skin penetration that actively limit their effectiveness after topical application. Therefore, nanocarriers such as liposomes, niosomes, microemulsions and nanoparticles have been widely investigated as delivery systems for antioxidants to improve their beneficial effects in the treatment of skin aging. In this article, the antioxidants most commonly used in anti-aging cosmetic products will be reviewed along with the nanocarriers designed to improve their safety and effectiveness.
La demanda de los productos naturales para el cuidado de piel es cada vez mayor ya que los consumidores los perciben como seguros. En la actualidad, los fabricantes de cosméticos centran sus esfuerzos en el desarrollo de productos naturales innovadores para abordar los signos de envejecimiento de la piel y, por tanto, satisfacer las necesidades de apariencia saludable y el bienestar de los consumidores. La suplementación con antioxidantes tópicos está considerada como una de las estrategias más prometedoras para prevenir o tratar el envejecimiento de la piel. Sin embargo, la mayoría de los antioxidantes que se utilizan actualmente en las formulaciones de cuidado de la piel muestran propiedades fisicoquímicas desfavorables como lipofilia o hidrofilia excesivas, inestabilidad química y escasa penetración de la piel, que limita su eficacia después de la aplicación tópica. Por lo tanto, nanovehículos tales como liposomas, niosomas, microemulsiones y nanopartículas han sido ampliamente investigados como sistemas de liberación para antioxidantes, para mejorar sus efectos beneficiosos en el tratamiento de envejecimiento de la piel. En este artículo serán revisados los antioxidantes más utilizados en productos cosméticos en la lucha contra el envejecimiento, junto con los nanovehículos diseñados para mejorar la seguridad y la eficacia.
Palabras Clave: Antienvejecimiento; antioxidante; cosmético; nanovehículo; sistema de liberación tópica.
Citation Format: Montenegro L (2014) Nanocarriers for skin delivery of cosmetic antioxidants. J Pharm Pharmacogn Res 2(4): 73-92.
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