Category Archives: Pharmacoepidemiology

CO 039: RATIONAL USE OF MEDICINES IN PRIMARY HEALTH CARE: POLYPHARMACY IN PEOPLE AGED 60 YEARS AND OLDER

J Pharm Pharmacogn Res 2(Suppl. 1): S21, 2014

Special supplement with the abstract book of LATINFARMA 2013

Oral Communication

CO 039: RATIONAL USE OF MEDICINES IN PRIMARY HEALTH CARE: POLYPHARMACY IN PEOPLE AGED 60 YEARS AND OLDER

Ponce LN, Brizuela NY.

Cátedra de Farmacología General. Facultad de Ciencias Médicas .Universidad Nacional de Córdoba. Argentina. E-mail: lucinuri2011@gmail.com
Abstract

Introduction: Pharmacotherapy in the elderly population is complicated by several factors that increase the risk of drugs. Rational use of medicines refers to the correct, proper and appropriate use of medicines. More than 50% of all medicines are prescribed, dispensed or sold inappropriately, and half of all patients fail to take medicines correctly. This article aims to highlight the increasing impact of polypharmacy in the elderly patients.

Methodology: The present study is prospective in nature, descriptive, cross sectional, carried out between February and May 2011, in a primary care clinic at a senior center in the city of Cordoba, Argentina.

Results: In this sample, 74.21% used from 5 to 8 medicines daily; all of them used to take each medication at least 3 times daily. In this sample, 73.04% had increased risk of adverse drug reaction (ADRs) and 78% came from different physicians. A third (34%) of the patients was treated predominately with cardiovascular diseases drugs. Metabolic diseases (25%), digestive illness (14.5%), neurological and psychiatric disorders (14.5%) and the others (14.5%). A quarter (25%) of the patients was treated with very little therapeutic value drugs.

Conclusions: Polypharmacy, as well as inappropriate prescribing, for the elderly is a major problem and a challenge that contributes to costs, adverse drug events, confusion, compliance issues, and errors in management. A systematic approach to drug monitoring is an important aspect of appropriate prescribing. Attention to prescribing of medications, consistent review of medication lists, and reevaluation of indications and outcomes of prescribing are essential to ensure that polypharmacy is minimized and safety for patients is maximized.

CO 038: FREQUENCY OF USE OF THE MONOCLONAL ANTIBODY RITUXIMAB ON THE NATIONAL CANCER INSTITUTE OF MEXICO: ONE YEAR EXPERIENCE

J Pharm Pharmacogn Res 2(Suppl. 1): S20, 2014

Special supplement with the abstract book of LATINFARMA 2013

Oral Communication

CO 038: FREQUENCY OF USE OF THE MONOCLONAL ANTIBODY RITUXIMAB ON THE NATIONAL CANCER INSTITUTE OF MEXICO: ONE YEAR EXPERIENCE

López-Gamboa M1,2, Aguilar-Ponce JL2, Espinoza-Zamora JR2, DavalosFiesco M2, Mena-Rodríguez FJ2, Castañeda-Hernández G1.

1Departamento de Farmacología, Centro de Estudios Avanzados del Instituto Politécnico Nacional, Av. Instituto Politécnico Nacional 2508, San Pedro Zacatenco, C.P. 07360, México D.F.
2Instituto Nacional de Cancerología; Av. San Fernando No. 22, Sol. Sección XVI, C.P. 14080, México D.F. E-mail: dralopezg@gmail.com
Abstract

Introduction: For the health care professionals and for the maker decisions staff on the hospital is very important have a real panorama about the use of the drugs in order to improve the patient attention. In Mexico for the oncology therapeutic segment, Rituximab the chimeric, anti-CD20 monoclonal antibody is registered for: a) the treatment of Non-Hodgking´s Lymphoma (CD20+); b) also combined with chemotherapy for previously untreated patients with relapsed/refractory of chronic lymphocytic leukemia.

Methods: With the aim of determine the Rituximab frequency usage on the National Cancer Institute of Mexico we made a retrospective analysis of the rituximab dispensation data from march 2012 to march 2013. Our collected data were: the pharmaceutical presentation and vials quantity of Rituximab dispensed per patient; and from the clinical record the data recorded included: clinical indication (diagnostic) result of CD20 test, weigh, height, age, and Rituximab dosage prescribed.

Results: During the twelve-month period, a total of 2663 Rituximab vials where dispensed from the Institute pharmacy, 1353 were 500 mg vials, and 1308 were 100 mg vials, distributed on 304 patients. The list of primary diagnostics included 75 different pathologies. All patients had immunohystochemical test, the 95% of the cases were positive to the CD 20 test, 4.7% of the patients had not report and 0.3% were negative to the CD20 test.

Conclusion: Even when Rituximab was prescribed for a diverse range of clinical conditions, the use of CD20 test was a standard followed on the patients, this practice showed the specific use of Rituximab.

CO 037: MEDICAL PRACTICE CONFIRMS CLINICAL TRIAL RESULTS OF THE USE OF INTRALESIONAL HUMAN RECOMBINANT EPIDERMAL GROWTH FACTOR IN ADVANCED DIABETIC FOOT ULCERS

J Pharm Pharmacogn Res 2(Suppl. 1): S20, 2014

Special supplement with the abstract book of LATINFARMA 2013

Oral Communication

CO 037: MEDICAL PRACTICE CONFIRMS CLINICAL TRIAL RESULTS OF THE USE OF INTRALESIONAL HUMAN RECOMBINANT EPIDERMAL GROWTH FACTOR IN ADVANCED DIABETIC FOOT ULCERS

López-Saura PA1, Yera-Alos IB1, Valenzuela-Silva C1, González-Díaz O1, del Río-Martín A1, Berlanga-Acosta J1, Fernández-Montequín JI2, Acevedo-Castro B1, López-Mola E1, Herrera-Martínez L1.

1Center for Genetic Engineering and Biotechnology, Havana, Cuba. E-mail: lopez.saura@cigb.edu.cu
2National Institute for Angiology and Vascular Surgery, Havana, Cuba.
Abstract

The intralesional injection of recombinant human epidermal growth factor (rhEGF) has been recently approved and introduced in several countries for the treatment of advanced diabetic foot ulcers (DFU), based on the results of five exploratory and one confirmatory, phase III clinical trials in 344 subjects. A significant stimulatory effect of this product on the healing process, given by granulation tissue development and re-epithelization was shown in these trials, as well as a reduction in lesion recurrences during follow-up, and a tendency to a reduction of the risk of amputations, with an acceptable safety profile. However, products not always perform the same way in current medical practice. The present review summarizes the clinical information available from the intralesional use of rhEGF for advanced DFU and shows that in this case the postmarketing experiences in more than 4000 subjects confirm the results of the clinical trials, with 75% probability of complete granulation response, 61% healing, and a 16% absolute and 71% relative reduction of the risk of amputation. The benefit includes ischemic patients. The safety profile in current practice was satisfactory. Serious adverse events are not attributable to the treatment but to the underlying conditions of the patients. No evidence of cancer promotion by the growth factor has been found. The benefitrisk ratio of the procedure is favorable.

CO 036: DRUG USE IN PREGNANT WOMEN

J Pharm Pharmacogn Res 2(Suppl. 1): S19, 2014

Special supplement with the abstract book of LATINFARMA 2013

Oral Communication

CO 036: DRUG USE IN PREGNANT WOMEN

Viroga S, Ramos C, Artagaveytia P, Speranza N, Tamosiunas G.

Department of Pharmacology and Therapeutics, School of Medicine, UdelaR, Uruguay.
Abstract

Introduction: There are few local data on drug use during pregnancy in our country. The selection of drugs in pregnancy must be based on efficacy and safety, taking into account the pharmacokinetic and pharmacodynamic changes that occur during pregnancy and the potential harm to the fetus.

Objective: To study the drug consumption profile in pregnant women in a maternal referential hospital in Uruguay.

Methods: Descriptional study, survey conducted by students of the College of Midwives from July to November 2010. The variables considered were: medications used, frequency of use of medications, source of prescription, teratogenic risk and use of abuse substances.

Results: 126 pregnant women (96.9%) used medications during their pregnancy. 364 drugs were used, including 64 active principles. The average use of drugs was 2.8 per woman. The most used drugs were iron, folic acid and dexamethasone. The 11.5% of the drugs were self prescribed (93% were NSAIDs). 37% of pregnant women consumed some abuse substance and 43% of those were consumed during the first trimester. Most used drugs corresponded to the B FDA category.

Conclusions: Despite popular belief, there is a high percentage of pregnant women using drugs. Contrary to the idea that drugs should not be used in pregnant women, there are certain drugs approved for its use in this population. The high percentage use of abuse substances, especially during the first trimester, is a concerning situation. The sample included in our study is not representative of the general population, but it allowed a situational assessment, pharmacoepidemiology important for our country. A future study with a larger number of patients will be needed. This study also resulted in the creation of research lines and allowed students to be involved in investigational activities.

Patrones de automedicación en Antofagasta

J Pharm Pharmacogn Res 1(2): 54-63, 2013.

Original article | Artículo original

Patrones de automedicación en clientes de una farmacia comunitaria de la ciudad de Antofagasta

[Patterns of self-medication in customers of a community pharmacy in the Antofagasta city]

Alejandrina Alucema*, Nicole Chavarría, Marisela Valdés

Departamento de Ciencias Farmacéuticas, Facultad de Ciencias, Universidad Católica del Norte, Angamos 0610, Antofagasta, Chile. * E-mail: aalucema@ucn.cl
Abstract

Context: Self-medication is the use of unprescribed drugs; this means that people obtain drugs on their own initiative and without the assistance of health professionals. This is an increasingly common practice among the population that can cause numerous problems, becoming a public health problem.
Aims: To determine the patterns of self-medication in customers who frequented a community pharmacy in the city of Antofagasta.
Methods: A survey was conducted to 297 users over 18 years and with adequate mental and communicative power to answer the questions, and attending the pharmacy to buy a drug without a prescription.
Results: The study revealed that of the 297 people who practiced self-medication, 41% do it with a frequency of at least once a month. The woman practiced in 64% and the men in 36%. The range of age of the studied group was between 31-50 years. The main reason to practice the self medication was to recognize symptoms (33%), within the most notable was the headache (11%). The therapeutic group of the most requested medicines was the NSAIDs (20%), and of them the paracetamol was the most used.
Conclusions: The results reveal that a high percentage of customers surveyed self-medicate, which shows this practice as a real problem, so it is necessary to educate people.

Keywords: Self-medication; pharmacoepidemiology; drug use.

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Resumen

Contexto: La automedicación es el uso de medicamentos sin prescripción médica, es decir, por iniciativa propia de las personas, y sin la asistencia de profesionales de la salud. Esta es una práctica cada día más común entre la población que puede causar numerosos problemas, llegando a convertirse en un problema de salud pública.
Objetivos: Determinar los patrones de automedicación en clientes de una farmacia comunitaria de la ciudad de Antofagasta.
Métodos: Se aplicó una encuesta a 297 personas mayores de 18 años, con la facultad mental y comunicativa adecuada para responder las preguntas, y que asistieron a la farmacia para comprar un fármaco sin receta médica.
Resultados: El estudio reveló que de las 297 personas que practicaban la automedicación, el 41% lo hacían con una frecuencia de al menos una vez al mes. Las mujeres lo hacían con el 64% y los hombres con el 36%. El rango de edad del grupo estudiado se encontraba entre los 31-50 años de edad. El principal motivo para incurrir en la automedicación fue el reconocer síntomas leves (33%), dentro de los cuales el más señalado fue la cefalea (11%). El grupo terapéutico de medicamentos más solicitados fueron los AINE (20%), y de ellos, el paracetamol fue el más usado.
Conclusiones: Los resultados revelan que un alto porcentaje de los clientes encuestados se automedican, lo que evidencia esta práctica como un problema real, por lo que se hace necesario educar a la población.

Palabras Clave: Automedicación; farmacoepidemiología; utilización de medicamentos.

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Citation Format: Alucema A, Chavarría N, Valdés M (2013) Patrones de automedicación en clientes de una farmacia comunitaria de la ciudad de Antofagasta. [Patterns of self-medication in customers of a community pharmacy in the Antofagasta city]. J Pharm Pharmacogn Res 1(2): 54-63.
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© 2013 Journal of Pharmacy & Pharmacognosy Research (JPPRes)