Characterization of Matricaria recutita tinctures

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J Pharm Pharmacogn Res 4(1): 18-24, 2016. DOI: https://doi.org/10.56499/jppres15.094_4.1.18 Original Article Physicochemical and chromatographic method of characterization of Matricaria recutita tinctures [Método de caracterización fisicoquímica y cromatográfica de tinturas de Matricaria recutita] Jonathan Parra1, Pedro M. García-Barrantes1, Gerardo Rodríguez2, Beatriz Badilla1 1Instituto de Investigaciones Farmacéuticas (INIFAR), Universidad de Costa Rica, San Pedro, San José, Costa Rica. 2Laboratorio de … Continue reading Characterization of Matricaria recutita tinctures

J Pharm Pharmacogn Res 4(1): 18-24, 2016.

DOI: https://doi.org/10.56499/jppres15.094_4.1.18

Original Article

Physicochemical and chromatographic method of characterization of Matricaria recutita tinctures

[Método de caracterización fisicoquímica y cromatográfica de tinturas de Matricaria recutita]

Jonathan Parra1, Pedro M. García-Barrantes1, Gerardo Rodríguez2, Beatriz Badilla1

1Instituto de Investigaciones Farmacéuticas (INIFAR), Universidad de Costa Rica, San Pedro, San José, Costa Rica.
2Laboratorio de Fitoquímica, Escuela de Química Industrial, Universidad Nacional de Costa Rica, Heredia, Costa Rica.
Abstract

Context: The pharmacological activity of medicinal products containing plant materials depends on their specific components. However, these components are not characterized in their entirety in all cases. Therefore, manufacturing processes must be duly characterized and validated.

Aims: To characterize a chamomile (Matricaria recutita) tincture through chemometric analysis of chromatographic data in order to establish quality parameters for its production.

Methods: Various chamomile tinctures were manufactured and the precision and robustness of the production process for each was verified. The physicochemical properties of the tinctures were characterized and their chromatographic digital fingerprints analysed through chemometric methods.

Results: A good correlation between the physicochemical characterization and the chromatographic analysis was demonstrated. The preparation methodology was proved to be repeatable as long as the source of the plant material is not altered.

Conclusions: The principal component multivariate analysis of chromatograms was a helpful and simple tool for the characterization and traceability of the production method.

Keywords: Liquid chromatography; Matricaria recutita; principal components analysis; tincture.

Resumen

Contexto: Para los productos medicinales que contienen material vegetal, la actividad farmacológica depende de sus componentes específicos; sin embargo, estos componentes no se encuentran completamente caracterizados en todos los casos; por ello, los procesos de manufactura deben ser caracterizados y validados.

Objetivos: Caracterizar una tintura de manzanilla (Matricaria recutita) por medio del análisis quimiométrico de datos cromatográficos para establecer parámetros de calidad en su producción.

Métodos: Se elaboraron varias tinturas de manzanilla, verificando la precisión y robustez del proceso de producción. Se caracterizó las propiedades fisicoquímicas de las tinturas y se analizó la huella digital cromatográfica por métodos quimiométricos.

Resultados: Se demostró una buena correlación entre la caracterización fisicoquímica y el análisis cromatográfico. El método de preparación demostró ser repetible si no se altera la fuente del material vegetal.

Conclusiones: El análisis multivariable por componentes principales de los cromatogramas demostró ser una herramienta útil y sencilla para la caracterización y trazabilidad del método de preparación.

Palabras Clave: Análisis por componentes principales; cromatografía líquida; Matricaria recutita; tintura.

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Citation Format: Jonathan Parra, Pedro M. García-Barrantes, Gerardo Rodríguez, Beatriz Badilla (2016) Physicochemical and chromatographic method of characterization of Matricaria recutita tinctures. J Pharm Pharmacogn Res 4(1): 18-24.DOI: https://doi.org/10.56499/jppres15.094_4.1.18
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© 2016 Journal of Pharmacy & Pharmacognosy Research (JPPRes)

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